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    gucy2d guanylate cyclase 2D, retinal [ Danio rerio (zebrafish) ]

    Gene ID: 140426, updated on 4-Jan-2025

    Summary

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    Official Symbol
    gucy2dprovided by ZNC
    Official Full Name
    guanylate cyclase 2D, retinalprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-011128-9
    See related
    Ensembl:ENSDARG00000026820 AllianceGenome:ZFIN:ZDB-GENE-011128-9
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gc3; GUCY2d1; RETGC-3
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within several processes, including cyclic nucleotide biosynthetic process; protein phosphorylation; and visual perception. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See gucy2d in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (38122854..38155069, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37522701..37560968, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-284e13.6 Neighboring gene uncharacterized LOC110438659 Neighboring gene si:ch211-284e13.11 Neighboring gene si:ch211-284e13.9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Iribarne M, et al. Sci Rep, 2017 Apr 5. PMID 28378769, Free PMC Article
    2. Forward genetic analysis of visual behavior in zebrafish. Muto A, et al. PLoS Genet, 2005 Nov. PMID 16311625, Free PMC Article
    3. Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors. Fries R, et al. PLoS One, 2013. PMID 23940527, Free PMC Article
    4. Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Rätscho N, et al. Biochim Biophys Acta, 2009 Jun. PMID 19168097
    5. Antisense RNAs during early vertebrate development are divided in groups with distinct features. Pillay S, et al. Genome Res, 2021 Jun. PMID 33795334, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These observations illustrate the interdependence of cyclic GMP metabolism regulators between Aipl1, Pde6c, and Gc3 in photoreceptors.
      Title: Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinal guanylyl cyclase 1
    Names
    guanylyl cyclase 3
    zat
    zatoichi
    NP_571941.1
    XP_005165318.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131866.1 → NP_571941.1  retinal guanylyl cyclase 1

      See identical proteins and their annotated locations for NP_571941.1

      Status: VALIDATED

      Source sequence(s)
      BC142906, BC163620, EB933544
      UniProtKB/TrEMBL
      A0A8M1P9F3, F1QSL9
      Related
      ENSDARP00000088541.4, ENSDART00000097770.6
      Conserved Domains (4) summary
      smart00044
      Location:879 → 1071
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:577 → 845
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      pfam07701
      Location:854 → 899
      HNOBA; Heme NO binding associated
      cd06371
      Location:78 → 466
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      38122854..38155069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165261.4 → XP_005165318.1  retinal guanylyl cyclase 1 isoform X1

      See identical proteins and their annotated locations for XP_005165318.1

      UniProtKB/TrEMBL
      A0A8M2BCH5
      Conserved Domains (4) summary
      cd06371
      Location:78 → 470
      PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      smart00044
      Location:883 → 1075
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:581 → 849
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      pfam07701
      Location:858 → 903
      HNOBA; Heme NO binding associated

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394596.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      275883..307247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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