dnah9 dynein, axonemal, heavy chain 9 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnah9provided by ZNC
Official Full Name: dynein, axonemal, heavy chain 9provided by ZNC
Primary source: ZFIN:ZDB-GENE-020925-1
See related: AllianceGenome:ZFIN:ZDB-GENE-020925-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Lrdr; lrdr1; dnahc11; fj30b09; zgc:63607; wu:fj30b09
Summary: Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Acts upstream of or within determination of heart left/right asymmetry and epithelial cilium movement involved in determination of left/right asymmetry. Located in extracellular region. Is expressed in several structures, including mesoderm; nervous system; neural tube; pleuroperitoneal region; and tail bud. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 40. Orthologous to human DNAH9 (dynein axonemal heavy chain 9). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 65

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (69881..145143, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (188452..196379, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease.
Title: Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease.
the endoplasmic reticulum Ca(2+) pump has a role in expression of no tail (ntl) and left-right dynein related (lrdr) in the dorsal forerunner cells during gastrulation
Title: Suppression of the endoplasmic reticulum calcium pump during zebrafish gastrulation affects left-right asymmetry of the heart and brain.
Node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.
Title: Conserved function for embryonic nodal cilia.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: dynein axonemal heavy chain 9

Names: dynein, axonemal, heavy chain 11; dynein, axonemal, heavy polypeptide 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001366550.1 → NP_001353479.1 dynein axonemal heavy chain 9

Status: VALIDATED

Source sequence(s)

CU607078, GDQH01007848, GFIL01008740

Conserved Domains (6) summary

pfam03028
Location:3767 → 4461

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:194 → 769

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1281 → 1678

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12781
Location:3416 → 3629

AAA_9; ATP-binding dynein motor region D5

cl21455
Location:2419 → 2690

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl25937
Location:3047 → 3390

MT; Microtubule-binding stalk of dynein motor