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    ppp2cab protein phosphatase 2 catalytic subunit alpha b [ Danio rerio (zebrafish) ]

    Gene ID: 393885, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp2cabprovided by ZNC
    Official Full Name
    protein phosphatase 2 catalytic subunit alpha bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-877
    See related
    Ensembl:ENSDARG00000053404 AllianceGenome:ZFIN:ZDB-GENE-040426-877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Ppp2ca; zgc:56064
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in mitotic cell cycle. Predicted to be located in chromosome, centromeric region; nucleus; and spindle pole. Predicted to be active in cytosol. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppp2cab in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (45351660..45363871, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (45310849..45323060, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transcription factor 7 Neighboring gene S-phase kinase-associated protein 1 Neighboring gene ubiquitin-conjugating enzyme E2B (RAD6 homolog) Neighboring gene CDKN2A interacting protein N-terminal like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. Xin Y, et al. Elife, 2019 Sep 17. PMID 31526479, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC56064

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Names
    protein phosphatase 2a, catalytic subunit, alpha
    NP_957205.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200911.3 → NP_957205.2  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

      Status: VALIDATED

      Source sequence(s)
      FP017197
      UniProtKB/TrEMBL
      A0A8M9PI57, Q7ZVE7
      Related
      ENSDARP00000125818.1, ENSDART00000151106.3
      Conserved Domains (1) summary
      cd07415
      Location:9 → 293
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      45351660..45363871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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