borcs5 BLOC-1 related complex subunit 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: borcs5provided by ZNC
Official Full Name: BLOC-1 related complex subunit 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-83
See related: Ensembl:ENSDARG00000077830 AllianceGenome:ZFIN:ZDB-GENE-041010-83
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: loh12cr1; zgc:92915; im:7155461
Summary: Predicted to be involved in lysosome localization; organelle transport along microtubule; and positive regulation of anterograde synaptic vesicle transport. Predicted to be located in lysosomal membrane. Predicted to be part of BORC complex and plus-end kinesin complex. Predicted to be active in cytoplasmic side of lysosomal membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human BORCS5 (BLOC-1 related complex subunit 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (17920668..17924763)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (17824253..17828363)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in lysosome localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosome localization	IEA Inferred from Electronic Annotation more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in organelle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in organelle transport along microtubule	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of anterograde synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of BORC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BORC complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic side of lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of plus-end kinesin complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BLOC-1-related complex subunit 5

Names: loss of heterozygosity 12 chromosomal region 1 protein homolog; loss of heterozygosity, 12, chromosomal region 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007052.2 → NP_001007053.1 BLOC-1-related complex subunit 5

See identical proteins and their annotated locations for NP_001007053.1

Status: PROVISIONAL

Source sequence(s)

BC083541

UniProtKB/Swiss-Prot

Q5XIX8

Related

ENSDARP00000087790.4, ENSDART00000093358.6

Conserved Domains (1) summary

pfam10158
Location:61 → 179

LOH1CR12; Tumour suppressor protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

17920668..17924763

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163008.5 → XP_005163065.1 BLOC-1-related complex subunit 5 isoform X1

UniProtKB/TrEMBL

A0A2R8PVF5, A0A8M2B9Z4

Related

ENSDARP00000144792.1, ENSDART00000185644.1

Conserved Domains (1) summary

pfam10158
Location:61 → 191

LOH1CR12; Tumour suppressor protein