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    znf513a zinc finger protein 513a [ Danio rerio (zebrafish) ]

    Gene ID: 568216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    znf513aprovided by ZNC
    Official Full Name
    zinc finger protein 513aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9895
    See related
    Ensembl:ENSDARG00000019961 AllianceGenome:ZFIN:ZDB-GENE-030131-9895
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb557; znf513; fi87d06; sb:cb557; wu:fi87d06; si:ch211-278j3.2; si:ch211-101l18.1
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within retina development in camera-type eye. Predicted to be active in nucleus. Is expressed in hindbrain; spinal cord; and telencephalon. Human ortholog(s) of this gene implicated in retinitis pigmentosa 58. Orthologous to human ZNF513 (zinc finger protein 513). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See znf513a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19423833..19432380)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19524250..19532797)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-71h2.2 Neighboring gene si:ch211-278j3.3 Neighboring gene sorting nexin 17 Neighboring gene all-trans retinoic acid-induced differentiation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A mutation in ZNF513, a putative regulator of photoreceptor development, causes autosomal-recessive retinitis pigmentosa. Li L, et al. Am J Hum Genet, 2010 Sep 10. PMID 20797688, Free PMC Article
    2. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 513a
    Names
    zinc finger protein 513

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309467.1 → NP_001296396.1  zinc finger protein 513a

      Status: PROVISIONAL

      Source sequence(s)
      BX276101, BX890544, CR931812
      UniProtKB/TrEMBL
      A0A8M1P772, R4GDS0
      Related
      ENSDARP00000126626.1, ENSDART00000152216.2
      Conserved Domains (3) summary
      COG5048
      Location:201 → 503
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:391 → 411
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:403 → 428
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      19423833..19432380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215539.1 → XP_068071640.1  zinc finger protein 513a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7B3, A0A8M9PBW4
    Nucleotide Protein Strain
    Heading Accession and Version

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