prdm14 PR domain containing 14 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prdm14provided by ZNC
Official Full Name: PR domain containing 14provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2709
See related: Ensembl:ENSDARG00000045371 AllianceGenome:ZFIN:ZDB-GENE-030131-2709
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: prmd14; fc16b12; wu:fc16b12
Summary: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis; negative regulation of heterochromatin formation; and stem cell population maintenance. Located in nucleus. Is expressed in several structures, including nervous system; neuroblasts; presumptive neural plate; spinal cord neural keel; and spinal cord neural tube. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human PRDM14 (PR/SET domain 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (14446517..14456642)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (14302090..14312223)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prdm14 regulates Caudal primary axon outgrowth through activation of islet2 expression.
Title: Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PR domain zinc finger protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163831.1 → NP_001157303.1 PR domain zinc finger protein 14

See identical proteins and their annotated locations for NP_001157303.1

Status: PROVISIONAL

Source sequence(s)

AY210801

UniProtKB/TrEMBL

Q6XSK8

Related

ENSDARP00000066719.1, ENSDART00000066720.2

Conserved Domains (4) summary

sd00017
Location:360 → 380

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:358 → 380

zf-C2H2; Zinc finger, C2H2 type

pfam00856
Location:203 → 265

SET; SET domain

pfam13465
Location:401 → 425

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

14446517..14456642

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162647.3 → XP_005162704.1 PR domain zinc finger protein 14 isoform X1

UniProtKB/TrEMBL

A0A8M2B9J9, F1QWQ9

Related

ENSDARP00000110909.1, ENSDART00000123674.3

Conserved Domains (4) summary

sd00017
Location:411 → 431

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:409 → 431

zf-C2H2; Zinc finger, C2H2 type

pfam00856
Location:214 → 316

SET; SET domain

pfam13465
Location:452 → 476

zf-H2C2_2; Zinc-finger double domain