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    mrc1a mannose receptor, C type 1a [ Danio rerio (zebrafish) ]

    Gene ID: 100286774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrc1aprovided by ZNC
    Official Full Name
    mannose receptor, C type 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090915-4
    See related
    Ensembl:ENSDARG00000102100 AllianceGenome:ZFIN:ZDB-GENE-090915-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mrc1; im:5629217
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in caudal hematopoietic tissue; post-vent region; trunk; vascular cord; and vasculature. Orthologous to human MRC1 (mannose receptor C-type 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mrc1a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (58892015..58952429, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (58589561..58649985, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene lysophospholipase 1 Neighboring gene uncharacterized LOC110439951 Neighboring gene uncharacterized LOC110439952 Neighboring gene 3-hydroxyacyl-CoA dehydratase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor. Li D, et al. Nat Med, 2019 Jul. PMID 31263281
    2. Meningeal lymphatic endothelial cells fulfill scavenger endothelial cell function and cooperate with microglia in waste removal from the brain. Huisman Y, et al. Glia, 2022 Jan. PMID 34487573
    3. Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake. Campbell F, et al. ACS Nano, 2018 Mar 27. PMID 29320626, Free PMC Article
    4. Differential Clearance of Aβ Species from the Brain by Brain Lymphatic Endothelial Cells in Zebrafish. Jeong YM, et al. Int J Mol Sci, 2021 Nov 2. PMID 34769316, Free PMC Article
    5. Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles. Arias-Alpizar G, et al. Nanomedicine, 2021 Jun. PMID 33838334

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    macrophage mannose receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      58892015..58952429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002662968.6 → XP_002663014.2  macrophage mannose receptor 1

      UniProtKB/TrEMBL
      A0A0R4INM0, A0A8M1RLY6
      Related
      ENSDARP00000137226.1, ENSDART00000167076.3
      Conserved Domains (5) summary
      smart00059
      Location:165 → 213
      FN2; Fibronectin type 2 domain
      cd00037
      Location:944 → 1072
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:361 → 485
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:31 → 108
      RICIN; Ricin-type beta-trefoil
      cd00161
      Location:37 → 108
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    Nucleotide Protein Strain
    Heading Accession and Version

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