U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cops4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) [ Danio rerio (zebrafish) ]

    Gene ID: 325592, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cops4provided by ZNC
    Official Full Name
    COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4317
    See related
    Ensembl:ENSDARG00000043732 AllianceGenome:ZFIN:ZDB-GENE-030131-4317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc90c08; zgc:77137; wu:fc90c08
    Summary
    Predicted to be located in nucleus and synaptic vesicle. Predicted to be part of COP9 signalosome. Is expressed in liver. Orthologous to human COPS4 (COP9 signalosome subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cops4 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (11355884..11367991)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (11397646..11410238)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene ints3 and nabp interacting protein Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene placenta associated 8, tandem duplicate 2 Neighboring gene placenta associated 8, tandem duplicate 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Loss of smarcad1a accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish. Han H, et al. Genes Chromosomes Cancer, 2021 Nov. PMID 34296799, Free PMC Article
    2. Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish. Tao T, et al. PLoS One, 2013. PMID 23593122, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    COP9 signalosome complex subunit 4
    Names
    signalosome subunit 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205556.1 → NP_991119.1  COP9 signalosome complex subunit 4

      See identical proteins and their annotated locations for NP_991119.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065617
      UniProtKB/Swiss-Prot
      Q6P0H6, Q6PHJ7
      Related
      ENSDARP00000064214.4, ENSDART00000064215.5
      Conserved Domains (2) summary
      COG5071
      Location:88 → 377
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:264 → 362
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      11355884..11367991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155593.5 → XP_005155650.1  COP9 signalosome complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A2R8QL66, A0A8M2B242
      Related
      ENSDARP00000153791.1, ENSDART00000193067.1
      Conserved Domains (2) summary
      COG5071
      Location:88 → 378
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:264 → 363
      PCI; PCI domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P0H6.1 GenPept UniProtKB/Swiss-Prot:Q6P0H6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous