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    wdr62 WD repeat domain 62 [ Danio rerio (zebrafish) ]

    Gene ID: 570949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdr62provided by ZNC
    Official Full Name
    WD repeat domain 62provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-291
    See related
    Ensembl:ENSDARG00000060312 AllianceGenome:ZFIN:ZDB-GENE-060503-291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb33e12; wu:fa11h05; wu:fb33e12; si:ch211-152c12.2
    Summary
    Acts upstream of or within heart development. Predicted to be active in mitotic spindle. Used to study microcephaly. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wdr62 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (5566180..5624639, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (5578335..5636799, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene arrestin, beta 1 Neighboring gene protein Atg16l2 Neighboring gene ATG16 autophagy related 16-like 2 (S. cerevisiae) Neighboring gene melanocortin 2 receptor accessory protein Neighboring gene URB1 ribosome biogenesis homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation. Hao L, et al. Clin Transl Med, 2022 Jul. PMID 35808830, Free PMC Article
    2. Digenic inheritance of human primary microcephaly delineates centrosomal and non-centrosomal pathways. Duerinckx S, et al. Hum Mutat, 2020 Feb. PMID 31696992, Free PMC Article
    3. Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Lin X, et al. Life (Basel), 2022 Sep 16. PMID 36143477, Free PMC Article
    4. Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression. Novorol C, et al. Open Biol, 2013 Oct 23. PMID 24153002, Free PMC Article
    5. Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish. He J, et al. J Genet Genomics, 2017 Dec 20. PMID 29246861

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC195119

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 62

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312680.1 → NP_001299609.1  WD repeat-containing protein 62

      Status: VALIDATED

      Source sequence(s)
      CR388135
      UniProtKB/TrEMBL
      A0A8M1P2F6, A0A8M2BGZ4, F6NPK9
      Related
      ENSDARP00000098255.4, ENSDART00000114410.6
      Conserved Domains (3) summary
      COG2319
      Location:354 → 740
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:490 → 524
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:355 → 736
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      5566180..5624639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169696.5 → XP_005169753.1  WD repeat-containing protein 62 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BGZ4, A0A8M2BH37
      Conserved Domains (3) summary
      COG2319
      Location:354 → 740
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:490 → 524
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:355 → 736
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_694487.8 → XP_699579.3  WD repeat-containing protein 62 isoform X1

      UniProtKB/TrEMBL
      A0A286YBK5, A0A8M2BGZ4, A0A8N7T879
      Related
      ENSDARP00000144578.1, ENSDART00000176446.2
      Conserved Domains (3) summary
      COG2319
      Location:354 → 740
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:490 → 524
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:355 → 736
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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