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    ulk1b unc-51 like autophagy activating kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 558848, updated on 15-Dec-2024

    Summary

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    Official Symbol
    ulk1bprovided by ZNC
    Official Full Name
    unc-51 like autophagy activating kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071203-2
    See related
    Ensembl:ENSDARG00000074481 AllianceGenome:ZFIN:ZDB-GENE-071203-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ulk1; si:dkey-11o18.7
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including axon extension; macroautophagy; and negative regulation of collateral sprouting. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in autophagosome; cytosol; and phagophore assembly site membrane. Is expressed in liver. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ulk1b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (14835251..14878244, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (14740904..14781524, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909433 Neighboring gene nucleolar complex associated 4 homolog Neighboring gene pseudouridine synthase 1 Neighboring gene matrix metallopeptidase 17a Neighboring gene splicing factor SWAP

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Metformin accelerates zebrafish heart regeneration by inducing autophagy. Xie F, et al. NPJ Regen Med, 2021 Oct 8. PMID 34625572, Free PMC Article
    2. Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos. Geng FS, et al. MicroPubl Biol, 2020 Dec 8. PMID 33313487, Free PMC Article
    3. Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer's Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter. Sun C, et al. Front Mol Neurosci, 2022. PMID 35754707, Free PMC Article
    4. Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. He C, et al. Autophagy, 2009 May. PMID 19221467, Free PMC Article
    5. Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Xin S, et al. Mar Drugs, 2024 Mar 27. PMID 38667765, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of collateral sprouting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase ULK2; serine/threonine-protein kinase ULK1
    Names
    unc-51 like autophagy activating kinase 1b
    unc-51-like kinase 1
    unc-51-like kinase 1b
    XP_002665971.2
    XP_005161178.1
    XP_021324714.1
    XP_068072121.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      14835251..14878244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161121.5 → XP_005161178.1  serine/threonine-protein kinase ULK1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B823
      Conserved Domains (3) summary
      smart00220
      Location:9 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12063
      Location:795 → 1006
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:6 → 272
      PKc_like; Protein Kinases, catalytic domain

    2. XM_002665925.7 → XP_002665971.2  serine/threonine-protein kinase ULK1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1RRT1, E9QIB7
      Related
      ENSDARP00000113763.2, ENSDART00000131237.3
      Conserved Domains (3) summary
      smart00220
      Location:9 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12063
      Location:796 → 1007
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:6 → 272
      PKc_like; Protein Kinases, catalytic domain

    3. XM_021469039.2 → XP_021324714.1  serine/threonine-protein kinase ULK1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PIT5
      Conserved Domains (2) summary
      pfam12063
      Location:795 → 1008
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:6 → 272
      PKc_like; Protein Kinases, catalytic domain

    4. XM_068216020.1 → XP_068072121.1  serine/threonine-protein kinase ULK1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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