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    bcor BCL6 corepressor [ Danio rerio (zebrafish) ]

    Gene ID: 402921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bcorprovided by ZNC
    Official Full Name
    BCL6 corepressorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040408-1
    See related
    Ensembl:ENSDARG00000017798 AllianceGenome:ZFIN:ZDB-GENE-040408-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; neural tube development; and retina morphogenesis in camera-type eye. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dental caries; eye disease (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including BCOR (BCL6 corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bcor in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (11144038..11200807)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (11114261..11170556)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882843 Neighboring gene uncharacterized LOC137488909 Neighboring gene ATPase H+ transporting accessory protein 2 Neighboring gene uncharacterized LOC103909557 Neighboring gene MID1 interacting protein 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. Naville M, et al. Nat Commun, 2015 Apr 24. PMID 25908307, Free PMC Article
    2. Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. Ng D, et al. Nat Genet, 2004 Apr. PMID 15004558
    3. Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression. Olsen AS, et al. Diabetes, 2012 Feb. PMID 22228713, Free PMC Article
    4. Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata. Lee J, et al. Hum Mol Genet, 2013 Sep 1. PMID 23669349, Free PMC Article
    5. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Zhang C, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31546038

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within retina morphogenesis in camera-type eye IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BCL-6 corepressor
    Names
    BCL6 co-repressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205626.1 → NP_991189.1  BCL-6 corepressor

      See identical proteins and their annotated locations for NP_991189.1

      Status: PROVISIONAL

      Source sequence(s)
      AY316593
      UniProtKB/TrEMBL
      A0A8M1PGH9, Q6W2J8
      Related
      ENSDARP00000047441.7, ENSDART00000047442.9
      Conserved Domains (5) summary
      cd00204
      Location:1480 → 1587
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1651 → 1767
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1490 → 1581
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1195 → 1429
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1486 → 1517
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      11144038..11200807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173943.5 → XP_005174000.1  BCL-6 corepressor isoform X1

      UniProtKB/TrEMBL
      A0A8M2BLL2, F1RCL8
      Related
      ENSDARP00000092882.4, ENSDART00000102106.5
      Conserved Domains (5) summary
      cd00204
      Location:1499 → 1606
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:1670 → 1786
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:1509 → 1600
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:1214 → 1448
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:1505 → 1536
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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