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    nit1 nitrilase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 447900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nit1provided by ZNC
    Official Full Name
    nitrilase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-65
    See related
    Ensembl:ENSDARG00000070116 AllianceGenome:ZFIN:ZDB-GENE-040912-65
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101630
    Summary
    Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Orthologous to human NIT1 (nitrilase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nit1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (7482523..7507493)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (7249166..7274119)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GCU) Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene prefoldin subunit 2 Neighboring gene chloride channel 3 Neighboring gene uncharacterized LOC100536361 Neighboring gene uncharacterized LOC101882062

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis. Zhang D, et al. Mech Dev, 2017 Feb. PMID 28132765
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    deaminated glutathione amidase
    NP_001004638.1
    XP_009301196.1
    XP_068078336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004638.1 → NP_001004638.1  deaminated glutathione amidase

      See identical proteins and their annotated locations for NP_001004638.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081382
      UniProtKB/TrEMBL
      Q66IE6
      Related
      ENSDARP00000093404.3, ENSDART00000102629.4
      Conserved Domains (1) summary
      cd07572
      Location:36 → 304
      nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      7482523..7507493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302921.4 → XP_009301196.1  deaminated glutathione amidase isoform X2

      UniProtKB/TrEMBL
      A0A8M3BAS6
      Conserved Domains (1) summary
      cd07572
      Location:8 → 276
      nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

    2. XM_068222235.1 → XP_068078336.1  deaminated glutathione amidase isoform X1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394672.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      45879..58260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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