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    ccn1 cellular communication network factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 403033, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ccn1provided by ZNC
    Official Full Name
    cellular communication network factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-3
    See related
    Ensembl:ENSDARG00000023062 AllianceGenome:ZFIN:ZDB-GENE-040426-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cyr61; zgc:85866; zCyr61-c23
    Summary
    Predicted to enable heparin binding activity and integrin binding activity. Acts upstream of or within fin regeneration. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain; endocrine system; epidermis; hypochord; and neural plate. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human CCN1 (cellular communication network factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ccn1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (45456380..45462757)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (45721185..45727562)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene aminoacyl tRNA synthetase complex interacting multifunctional protein 1b Neighboring gene nephronectin Neighboring gene zinc finger HIT-type containing 6 Neighboring gene collagen alpha-1(XXIV) chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype. Sinnberg T, et al. Mol Cancer, 2018 Feb 17. PMID 29454361, Free PMC Article
    2. Optogenetic control of YAP cellular localisation and function. Toh PJY, et al. EMBO Rep, 2022 Sep 5. PMID 35876586, Free PMC Article
    3. LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion. Camillo C, et al. J Cell Biol, 2021 Nov 1. PMID 34581723, Free PMC Article
    4. Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway. Xu D, et al. FASEB J, 2018 Aug. PMID 29529391
    5. Low doses of ionizing radiation enhance angiogenesis and consequently accelerate post-embryonic development but not regeneration in zebrafish. Marques FG, et al. Sci Rep, 2020 Feb 21. PMID 32081879, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CCN family member 1
    Names
    cysteine-rich, angiogenic inducer, 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001826.2 → NP_001001826.2  CCN family member 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CU672235
      UniProtKB/TrEMBL
      A0A8M1MZN6, F1QL10
      Related
      ENSDARP00000036965.5, ENSDART00000036631.6
      Conserved Domains (3) summary
      smart00041
      Location:279 → 348
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:95 → 154
      VWC; von Willebrand factor (vWF) type C domain
      pfam00219
      Location:21 → 73
      IGFBP; Insulin-like growth factor binding protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      45456380..45462757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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