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    znf143b zinc finger protein 143b [ Danio rerio (zebrafish) ]

    Gene ID: 393954, updated on 15-Dec-2024

    Summary

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    Official Symbol
    znf143bprovided by ZNC
    Official Full Name
    zinc finger protein 143bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1586
    See related
    Ensembl:ENSDARG00000041581 AllianceGenome:ZFIN:ZDB-GENE-040426-1586
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Zfp143; znf143; zgc:66276
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development and positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in forebrain; hindbrain; and midbrain. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See znf143b in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (16924873..16937110, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (16935614..16948060, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene switching B cell complex subunit SWAP70b Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene si:dkey-8l13.5 Neighboring gene si:ch211-242e8.1 Neighboring gene A kinase (PRKA) interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Overexpression of MMACHC Prevents Craniofacial Phenotypes Caused by Knockdown of znf143b. Perez I, et al. Am J Undergrad Res, 2023 Jun. PMID 38617190, Free PMC Article
    2. Two paralogous znf143 genes in zebrafish encode transcriptional activator proteins with similar functions but expressed at different levels during early development. Huning L, et al. BMC Mol Cell Biol, 2020 Jan 22. PMID 31969120, Free PMC Article
    3. CHD8short, a naturally-occurring truncated form of a chromatin remodeler lacking the helicase domain, is a potent transcriptional coregulator. Kunkel GR, et al. Gene, 2018 Jan 30. PMID 29079199
    4. Characterization of snRNA and snRNA-type genes in the pufferfish Fugu rubripes. Myslinski E, et al. Gene, 2004 Apr 14. PMID 15087134
    5. The transcriptional activator ZNF143 is essential for normal development in zebrafish. Halbig KM, et al. BMC Mol Biol, 2012 Jan 23. PMID 22268977, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two paralogous znf143 genes in zebrafish encode transcriptional activator proteins with similar functions but expressed at different levels during early development.
      Title: Two paralogous znf143 genes in zebrafish encode transcriptional activator proteins with similar functions but expressed at different levels during early development.
    2. The knockdown of the transcriptional activator ZNF143 by injection of translational-blocking Morpholino Oligonucleotides causes many significant phenotypic effects in zebrafish embryos
      Title: The transcriptional activator ZNF143 is essential for normal development in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66276

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 143
    Names
    selenocysteine tRNA activating factor
    selenocysteine tRNA gene transcription-activating factor
    staf
    NP_957273.1
    XP_005159129.1
    XP_005159130.1
    XP_009291820.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200979.1 → NP_957273.1  zinc finger protein 143

      See identical proteins and their annotated locations for NP_957273.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055577
      UniProtKB/TrEMBL
      Q7SXJ2
      Related
      ENSDARP00000090890.3, ENSDART00000100117.3
      Conserved Domains (4) summary
      COG5048
      Location:166 → 317
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:179 → 201
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:253 → 280
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:269 → 349
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      16924873..16937110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159073.5 → XP_005159130.1  zinc finger protein 143 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B5J5
      Conserved Domains (3) summary
      sd00017
      Location:228 → 250
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:302 → 329
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:318 → 398
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_005159072.5 → XP_005159129.1  zinc finger protein 143 isoform X1

      See identical proteins and their annotated locations for XP_005159129.1

      UniProtKB/Swiss-Prot
      A0AUQ7, Q1LYE3, Q6VQB1
      Related
      ENSDARP00000122626.1, ENSDART00000136541.3
      Conserved Domains (3) summary
      sd00017
      Location:232 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:306 → 333
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:322 → 402
      zf-C2H2_8; C2H2-type zinc ribbon

    3. XM_009293545.4 → XP_009291820.1  zinc finger protein 143 isoform X1

      See identical proteins and their annotated locations for XP_009291820.1

      UniProtKB/Swiss-Prot
      A0AUQ7, Q1LYE3, Q6VQB1
      Related
      ENSDARP00000009795.8, ENSDART00000022640.10
      Conserved Domains (3) summary
      sd00017
      Location:232 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:306 → 333
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:322 → 402
      zf-C2H2_8; C2H2-type zinc ribbon

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395017.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      629645..641882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395338.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      137960..149139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LYE3.2 GenPept UniProtKB/Swiss-Prot:Q1LYE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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