cdc42ep4a CDC42 effector protein (Rho GTPase binding) 4a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdc42ep4aprovided by ZNC
Official Full Name: CDC42 effector protein (Rho GTPase binding) 4aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040704-22
See related: Ensembl:ENSDARG00000101457 AllianceGenome:ZFIN:ZDB-GENE-040704-22
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb55a05; cdc42ep4; zgc:91889; wu:fb55a05
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Is expressed in presumptive cephalic mesoderm. Orthologous to human CDC42EP4 (CDC42 effector protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (50949756..50998560, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (49909833..49958594, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb55a05.x1 (e-PCR)
- UniSTS:190721

AI477044 (e-PCR)
- UniSTS:206530

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pseudopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cdc42 effector protein 4a

Names: CDC42 effector protein (Rho GTPase binding) 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002183.1 → NP_001002183.1 cdc42 effector protein 4a

See identical proteins and their annotated locations for NP_001002183.1

Status: PROVISIONAL

Source sequence(s)

BC074044

UniProtKB/TrEMBL

A0A8M9P5X2, Q6GMK1

Related

ENSDARP00000141543.1, ENSDART00000163810.2

Conserved Domains (2) summary

pfam14957
Location:107 → 200

BORG_CEP; Cdc42 effector

cl00113
Location:25 → 52

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

50949756..50998560 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164442.5 → XP_005164499.1 cdc42 effector protein 4a isoform X1

See identical proteins and their annotated locations for XP_005164499.1

UniProtKB/TrEMBL

A0A8M9P5X2, Q6GMK1

Related

ENSDARP00000132079.1, ENSDART00000157735.2

Conserved Domains (2) summary

pfam14957
Location:107 → 200

BORG_CEP; Cdc42 effector

cl00113
Location:25 → 52

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_021470182.2 → XP_021325857.1 cdc42 effector protein 4a isoform X1

UniProtKB/TrEMBL

A0A8M9P5X2, Q6GMK1

Conserved Domains (2) summary

pfam14957
Location:107 → 200

BORG_CEP; Cdc42 effector

cl00113
Location:25 → 52

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...