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    tpd52 tumor protein D52 [ Danio rerio (zebrafish) ]

    Gene ID: 559992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tpd52provided by ZNC
    Official Full Name
    tumor protein D52provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-680
    See related
    Ensembl:ENSDARG00000061713 AllianceGenome:ZFIN:ZDB-GENE-060503-680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-203l9.2; si:ch211-203l9.3
    Summary
    Predicted to enable thymidine kinase activity. Acts upstream of or within positive regulation of hematopoietic stem cell proliferation. Predicted to be active in cytoplasm. Orthologous to human TPD52 (tumor protein D52). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tpd52 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (31904912..31941615)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (32317594..32351836)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909257 Neighboring gene zinc finger and BTB domain containing 10 Neighboring gene zinc finger protein 704 Neighboring gene phosphoprotein membrane anchor with glycosphingolipid microdomains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation. Kang JW, et al. J Cell Biochem, 2021 Apr. PMID 33166425
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables thymidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor protein D52
    NP_001038486.1
    XP_005159684.1
    XP_005159685.1
    XP_005159686.1
    XP_005159687.1
    XP_009292571.1
    XP_017207734.1
    XP_017207735.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045021.2 → NP_001038486.1  tumor protein D52

      See identical proteins and their annotated locations for NP_001038486.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133913
      UniProtKB/TrEMBL
      A0A8M1N9T8, A3KNM2
      Related
      ENSDARP00000082773.3, ENSDART00000088340.5
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 170
      TPD52; Tumour protein D52 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      31904912..31941615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159630.5 → XP_005159687.1  tumor protein D52 isoform X5

      UniProtKB/TrEMBL
      A0A0R4IDA7, A0A8M2B679
      Related
      ENSDARP00000132427.1, ENSDART00000162297.2
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 193
      TPD52; Tumour protein D52 family

    2. XM_017352246.3 → XP_017207735.1  tumor protein D52 isoform X6

      UniProtKB/TrEMBL
      A0A8M6Z2Z5, I3IT45
      Related
      ENSDARP00000126099.1, ENSDART00000151280.3

    3. XM_009294296.4 → XP_009292571.1  tumor protein D52 isoform X7

      UniProtKB/TrEMBL
      A0A8M3AL07
      Conserved Domains (1) summary
      pfam04201
      Location:48 → 166
      TPD52; Tumour protein D52 family

    4. XM_005159627.5 → XP_005159684.1  tumor protein D52 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6H9
      Conserved Domains (1) summary
      pfam04201
      Location:48 → 229
      TPD52; Tumour protein D52 family

    5. XM_017352245.3 → XP_017207734.1  tumor protein D52 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YWD3

    6. XM_005159628.5 → XP_005159685.1  tumor protein D52 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B6F1
      Conserved Domains (1) summary
      pfam04201
      Location:48 → 220
      TPD52; Tumour protein D52 family

    7. XM_005159629.5 → XP_005159686.1  tumor protein D52 isoform X4

      UniProtKB/TrEMBL
      A0A8M2B6B7
      Conserved Domains (1) summary
      pfam04201
      Location:48 → 206
      TPD52; Tumour protein D52 family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395053.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      53832..89453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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