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    zgc:56095 zgc:56095 [ Danio rerio (zebrafish) ]

    Gene ID: 406286, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zgc:56095provided by ZNC
    Official Full Name
    zgc:56095provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1948
    See related
    Ensembl:ENSDARG00000018461 AllianceGenome:ZFIN:ZDB-GENE-040426-1948
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa11g10; fb23g05; zgc:86792; wu:fa11g10; wu:fb23g05
    Summary
    Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to act upstream of or within intracellular iron ion homeostasis and iron ion transport. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zgc:56095 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (7741604..7746478)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (7712285..7717159)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene bloodthirsty-related gene family, member 33 Neighboring gene receptor-type tyrosine-protein phosphatase H Neighboring gene RPGR interacting protein 1 Neighboring gene protein tyrosine phosphatase receptor type H Neighboring gene si:dkey-197c15.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ferritin, lower subunit-like; ferritin, lower subunit-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213013.1 → NP_998178.1  Ferritin, lower subunit-like

      See identical proteins and their annotated locations for NP_998178.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045905
      UniProtKB/TrEMBL
      Q7ZVD6
      Related
      ENSDARP00000011510.7, ENSDART00000009687.8
      Conserved Domains (2) summary
      cd01056
      Location:9 → 171
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:13 → 154
      Ferritin; Ferritin-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      7741604..7746478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470123.2 → XP_021325798.1  ferritin, lower subunit-like isoform X1

      UniProtKB/TrEMBL
      A0A8M9PFW3
      Related
      ENSDARP00000151034.1, ENSDART00000193229.1
      Conserved Domains (1) summary
      cd01056
      Location:9 → 171
      Euk_Ferritin; eukaryotic ferritins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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