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    dnajc10 DnaJ (Hsp40) homolog, subfamily C, member 10 [ Danio rerio (zebrafish) ]

    Gene ID: 557858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnajc10provided by ZNC
    Official Full Name
    DnaJ (Hsp40) homolog, subfamily C, member 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070327-1
    See related
    Ensembl:ENSDARG00000074727 AllianceGenome:ZFIN:ZDB-GENE-070327-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162218
    Summary
    Predicted to enable misfolded protein binding activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; and protein-disulfide reductase activity. Predicted to be involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Orthologous to human DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dnajc10 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (44870459..44897503, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (45069507..45096551, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene frizzled related protein Neighboring gene uncharacterized LOC137496433 Neighboring gene zgc:66484 Neighboring gene villin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-3906 regulates fast muscle differentiation through modulating the target gene homer-1b in zebrafish embryos. Lin CY, et al. PLoS One, 2013. PMID 23936160, Free PMC Article
    2. CERKL knockdown causes retinal degeneration in zebrafish. Riera M, et al. PLoS One, 2013. PMID 23671706, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC162218

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 10
    NP_001077016.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083547.1 → NP_001077016.1  dnaJ homolog subfamily C member 10

      See identical proteins and their annotated locations for NP_001077016.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134925
      UniProtKB/TrEMBL
      A0A8M1NCC7, A4IG47
      Related
      ENSDARP00000103524.2, ENSDART00000110697.3
      Conserved Domains (7) summary
      COG0484
      Location:33 → 129
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      cd02961
      Location:348 → 443
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      cd03003
      Location:128 → 228
      PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
      cd03004
      Location:552 → 660
      PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
      TIGR01130
      Location:129 → 648
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam00226
      Location:33 → 95
      DnaJ; DnaJ domain
      cl00388
      Location:276 → 318
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      44870459..44897503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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