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    sh3bgr SH3 domain binding glutamate-rich protein [ Danio rerio (zebrafish) ]

    Gene ID: 445130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sh3bgrprovided by ZNC
    Official Full Name
    SH3 domain binding glutamate-rich proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-27
    See related
    Ensembl:ENSDARG00000021633 AllianceGenome:ZFIN:ZDB-GENE-040801-27
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:100896
    Summary
    Predicted to be active in cytoplasm. Is expressed in several structures, including intestine; nervous system; otic vesicle; pectoral fin; and somite border. Orthologous to human SH3BGR (SH3 domain binding glutamate rich protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sh3bgr in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (5923853..5970632)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (5935977..5980821)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosome binding domain 1a Neighboring gene guided entry of tail-anchored proteins factor 1 Neighboring gene immunoglobulin superfamily, member 5b Neighboring gene Purkinje cell protein 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression patterns of SH3BGR family members in zebrafish development. Tong F, et al. Dev Genes Evol, 2016 Jul. PMID 27233781
    2. Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Chen WC, et al. Sci Adv, 2016 Nov. PMID 28138518, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-binding glutamic acid-rich protein
    Names
    SH3 domain binding glutamic acid-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003524.2 → NP_001003524.1  SH3 domain-binding glutamic acid-rich protein isoform 2

      See identical proteins and their annotated locations for NP_001003524.1

      Status: VALIDATED

      Source sequence(s)
      CR848754, CT573306, CU896562, FO704887
      UniProtKB/TrEMBL
      A0A8M1N1H7, A0A8M9QBY3, Q6DEH8
      Related
      ENSDARP00000107708.1, ENSDART00000121529.2
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    2. NM_001362476.1 → NP_001349405.1  SH3 domain-binding glutamic acid-rich protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      CR848754, CT573306, CU896562, FO704887
      UniProtKB/TrEMBL
      A0A8M2BGX9, A0A8M9QLC6
      Related
      ENSDARP00000126846.1, ENSDART00000152520.3
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    3. NM_001362477.1 → NP_001349406.1  SH3 domain-binding glutamic acid-rich protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      CR848754, CT573306, CU896562, FO704887
      UniProtKB/TrEMBL
      A0A8M9Q0A5
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    4. NM_001362478.1 → NP_001349407.1  SH3 domain-binding glutamic acid-rich protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      CR848754, CT573306, CU896562, FO704887
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    5. NM_001362479.1 → NP_001349408.1  SH3 domain-binding glutamic acid-rich protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      CR848754, CT573306, CU896562, FO704887
      UniProtKB/TrEMBL
      A0A8M2BH34
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    6. NM_001362480.1 → NP_001349409.1  SH3 domain-binding glutamic acid-rich protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      CR848754, CT573306, CU896562, FO704887
      UniProtKB/TrEMBL
      A0A8M2BH04
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      5923853..5970632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169682.5 → XP_005169739.1  SH3 domain-binding glutamic acid-rich protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2BH31, A0A8M9QLC6
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    2. XM_009291452.4 → XP_009289727.1  SH3 domain-binding glutamic acid-rich protein isoform X2

      UniProtKB/TrEMBL
      A0A8M3AH20, A0A8M9QLC6
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    3. XM_009291451.4 → XP_009289726.1  SH3 domain-binding glutamic acid-rich protein isoform X3

      UniProtKB/TrEMBL
      A0A8M3APJ1, A0A8M9QLC6
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    4. XM_009291453.4 → XP_009289728.1  SH3 domain-binding glutamic acid-rich protein isoform X4

      UniProtKB/TrEMBL
      A0A8M3B0Q6, A0A8M9QLC6
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    5. XM_068213517.1 → XP_068069618.1  SH3 domain-binding glutamic acid-rich protein isoform X7

      UniProtKB/TrEMBL
      A0A8M9QLC6

    6. XM_068213515.1 → XP_068069616.1  SH3 domain-binding glutamic acid-rich protein isoform X5

      UniProtKB/TrEMBL
      A0A8M9QLC6

    7. XM_068213516.1 → XP_068069617.1  SH3 domain-binding glutamic acid-rich protein isoform X6

      UniProtKB/TrEMBL
      A0A8M9QLC6

    8. XM_005169685.5 → XP_005169742.1  SH3 domain-binding glutamic acid-rich protein isoform X8

      UniProtKB/TrEMBL
      A0A8M2BH02, A0A8M9QLC6
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    9. XM_068213518.1 → XP_068069619.1  SH3 domain-binding glutamic acid-rich protein isoform X10

      UniProtKB/TrEMBL
      A0A8M2BGX9, A0A8M9QLC6

    10. XM_068213519.1 → XP_068069620.1  SH3 domain-binding glutamic acid-rich protein isoform X11

      UniProtKB/TrEMBL
      A0A8M1N1H7, A0A8M9QBY3, Q6DEH8

    11. XM_068213520.1 → XP_068069621.1  SH3 domain-binding glutamic acid-rich protein isoform X11

      UniProtKB/TrEMBL
      A0A8M9Q0A5

    12. XM_068213521.1 → XP_068069622.1  SH3 domain-binding glutamic acid-rich protein isoform X12

    13. XM_068213522.1 → XP_068069623.1  SH3 domain-binding glutamic acid-rich protein isoform X14

    14. XM_009291457.4 → XP_009289732.1  SH3 domain-binding glutamic acid-rich protein isoform X15

      UniProtKB/TrEMBL
      A0A8M3AI92
      Related
      ENSDARP00000118869.2, ENSDART00000145827.4
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    15. XM_005169686.5 → XP_005169743.1  SH3 domain-binding glutamic acid-rich protein isoform X9

      UniProtKB/TrEMBL
      A0A8M2BHI0
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    16. XM_005169688.5 → XP_005169745.1  SH3 domain-binding glutamic acid-rich protein isoform X13

      UniProtKB/TrEMBL
      A0A8M2BGZ0
      Conserved Domains (1) summary
      cd03030
      Location:2 → 97
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    17. XM_068213523.1 → XP_068069624.1  SH3 domain-binding glutamic acid-rich protein isoform X16

    18. XM_068213524.1 → XP_068069625.1  SH3 domain-binding glutamic acid-rich protein isoform X17

      UniProtKB/TrEMBL
      A0A8M2BH34

    19. XM_068213525.1 → XP_068069626.1  SH3 domain-binding glutamic acid-rich protein isoform X17

      UniProtKB/TrEMBL
      A0A8M2BH04

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394932.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      231906..251586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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