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    serac1 serine active site containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 568022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    serac1provided by ZNC
    Official Full Name
    serine active site containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040616-1
    See related
    Ensembl:ENSDARG00000056121 AllianceGenome:ZFIN:ZDB-GENE-040616-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum; membrane; and mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Orthologous to human SERAC1 (serine active site containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See serac1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (26048304..26060154, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (26149214..26161101, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-12h9.6 Neighboring gene general transcription factor IIH, polypeptide 5 Neighboring gene myc target 1a Neighboring gene spectrin repeat containing, nuclear envelope 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein SERAC1
    Names
    serine active site-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030286.1 → NP_001025457.1  protein SERAC1

      Status: PROVISIONAL

      Source sequence(s)
      AL954831
      UniProtKB/TrEMBL
      A0A8M1N7H8
      Conserved Domains (2) summary
      cd00020
      Location:220 → 304
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:187 → 215
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      26048304..26060154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468495.2 → XP_021324170.1  protein SERAC1 isoform X1

      UniProtKB/Swiss-Prot
      Q5SNQ7, Q5SNQ8
      UniProtKB/TrEMBL
      A0A8M9PSW7
      Conserved Domains (1) summary
      sd00043
      Location:259 → 287
      ARM; armadillo repeat [structural motif]

    2. XM_005160583.5 → XP_005160640.1  protein SERAC1 isoform X1

      See identical proteins and their annotated locations for XP_005160640.1

      UniProtKB/Swiss-Prot
      Q5SNQ7, Q5SNQ8
      UniProtKB/TrEMBL
      A0A8M9PSW7
      Related
      ENSDARP00000126448.1, ENSDART00000151950.3
      Conserved Domains (1) summary
      sd00043
      Location:259 → 287
      ARM; armadillo repeat [structural motif]

    3. XM_021468494.2 → XP_021324169.1  protein SERAC1 isoform X1

      UniProtKB/Swiss-Prot
      Q5SNQ7, Q5SNQ8
      UniProtKB/TrEMBL
      A0A8M9PSW7
      Conserved Domains (1) summary
      sd00043
      Location:259 → 287
      ARM; armadillo repeat [structural motif]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395074.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      163685..175170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SNQ7.1 GenPept UniProtKB/Swiss-Prot:Q5SNQ7

    Gene LinkOut

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