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    dstyk dual serine/threonine and tyrosine protein kinase [ Danio rerio (zebrafish) ]

    Gene ID: 402922, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dstykprovided by ZNC
    Official Full Name
    dual serine/threonine and tyrosine protein kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040826-2
    See related
    Ensembl:ENSDARG00000000853 AllianceGenome:ZFIN:ZDB-GENE-040826-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ripk5; zgc:136421
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Involved in embryonic organ development. Acts upstream of or within notochord cell vacuolation and notochord morphogenesis. Predicted to be located in anchoring junction; apical plasma membrane; and basolateral plasma membrane. Predicted to be active in cytoplasm. Is expressed in head and notochord. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See dstyk in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (473263..506956, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (435540..469246, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit beta Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene NUAK family, SNF1-like kinase, 2 Neighboring gene cyclin D3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Notochord vacuoles absorb compressive bone growth during zebrafish spine formation. Bagwell J, et al. Elife, 2020 Jan 29. PMID 31995030, Free PMC Article
    2. Mutations in DSTYK and dominant urinary tract malformations. Sanna-Cherchi S, et al. N Engl J Med, 2013 Aug 15. PMID 23862974, Free PMC Article
    3. Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway. Sun X, et al. Nat Commun, 2020 Jan 24. PMID 31980602, Free PMC Article
    4. Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. Peng J, et al. Biochim Biophys Acta, 2006 Nov-Dec. PMID 17123648, Free PMC Article
    5. Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. Suarez-Bregua P, et al. FASEB J, 2017 Feb. PMID 28148780, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings reveal a key role of DSTYK in notochord vacuole biogenesis, notochord morphogenesis and spine development through mTORC1/TFEB pathway
      Title: Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136421

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to fibroblast growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within notochord cell vacuolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within notochord morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dual serine/threonine and tyrosine protein kinase
    Names
    dusty PK
    dusty protein kinase
    receptor interacting protein kinase 5
    receptor-interacting serine/threonine-protein kinase 5
    NP_991190.2
    XP_005168327.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205627.2 → NP_991190.2  dual serine/threonine and tyrosine protein kinase

      See identical proteins and their annotated locations for NP_991190.2

      Status: PROVISIONAL

      Source sequence(s)
      AY429681
      UniProtKB/Swiss-Prot
      Q4VSN1
      Related
      ENSDARP00000067636.5, ENSDART00000067637.7
      Conserved Domains (2) summary
      smart00220
      Location:587 → 831
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13975
      Location:585 → 846
      PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      473263..506956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168270.5 → XP_005168327.1  dual serine/threonine and tyrosine protein kinase isoform X1

      See identical proteins and their annotated locations for XP_005168327.1

      UniProtKB/Swiss-Prot
      Q0VFW4, Q4VSN1, Q5VJL5, Q6NWI9, Q6XUW8
      Related
      ENSDARP00000097423.3, ENSDART00000106645.6
      Conserved Domains (2) summary
      smart00220
      Location:615 → 859
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13975
      Location:613 → 874
      PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VSN1.1 GenPept UniProtKB/Swiss-Prot:Q4VSN1

    Gene LinkOut

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