ptpn23a protein tyrosine phosphatase, non-receptor type 23, a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptpn23aprovided by ZNC
Official Full Name: protein tyrosine phosphatase, non-receptor type 23, aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-100921-24
See related: Ensembl:ENSDARG00000070124 AllianceGenome:ZFIN:ZDB-GENE-100921-24
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptp23a; si:dkey-201i6.7
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in early endosome to late endosome transport; endocytic recycling; and protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within multivesicular body sorting pathway and protein dephosphorylation. Predicted to be active in endosome. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (41112346..41131621, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (41162312..41181585, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 23

Names: His domain-containing protein tyrosine phosphatase a

NP_001189436.1

EC 3.1.3.48

XP_005158252.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202507.1 → NP_001189436.1 tyrosine-protein phosphatase non-receptor type 23

Status: VALIDATED

Source sequence(s)

BX511123, CT027682

UniProtKB/TrEMBL

A0A8M1NYL1, F1R1D1

Related

ENSDARP00000093424.4, ENSDART00000102649.5

Conserved Domains (5) summary

cd09234
Location:346 → 682

V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

cd09239
Location:2 → 341

BRO1_HD-PTP_like; Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

cd00047
Location:1533 → 1763

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:1532 → 1764

Y_phosphatase; Protein-tyrosine phosphatase

pfam13949
Location:400 → 685

ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

41112346..41131621 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158195.5 → XP_005158252.1 tyrosine-protein phosphatase non-receptor type 23 isoform X1

UniProtKB/TrEMBL

A0A8M2B4I3, F1Q653

Related

ENSDARP00000115750.1, ENSDART00000145956.2

Conserved Domains (5) summary

cd09234
Location:362 → 698

V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

cd09239
Location:2 → 357

BRO1_HD-PTP_like; Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

cd00047
Location:1549 → 1779

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:1548 → 1780

Y_phosphatase; Protein-tyrosine phosphatase

pfam13949
Location:416 → 701

ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV