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    tmsb2 thymosin beta 2 [ Danio rerio (zebrafish) ]

    Gene ID: 566329, updated on 4-Jan-2025

    Summary

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    Official Symbol
    tmsb2provided by ZNC
    Official Full Name
    thymosin beta 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070126-5
    See related
    Ensembl:ENSDARG00000092970 AllianceGenome:ZFIN:ZDB-GENE-070126-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gb:bi428446; si:ch211-11c15.3
    Summary
    Predicted to enable actin monomer binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in brain; neural keel; and trigeminal ganglion. Orthologous to human TMSB10 (thymosin beta 10). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See tmsb2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (34486717..34488993)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487601 Neighboring gene uncharacterized LOC137487530 Neighboring gene protein Wnt-8a ORF2 Neighboring gene uncharacterized LOC137487602 Neighboring gene wingless-type MMTV integration site family, member 8a Neighboring gene lymphocyte cytosolic protein 2b

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007125.7 Chromosome 14 Reference GRCz11 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Vertebrate beta-thymosins: conserved synteny reveals the relationship between those of bony fish and of land vertebrates. Edwards J. FEBS Lett, 2010 Mar 5. PMID 20138884
    2. Thymosin beta4 regulates cardiac valve formation via endothelial-mesenchymal transformation in zebrafish embryos. Shin SH, et al. Mol Cells, 2014 Apr. PMID 24732964, Free PMC Article
    3. Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart. Bise T, et al. NPJ Regen Med, 2019. PMID 30701084, Free PMC Article
    4. Gene expression analysis of zebrafish heart regeneration. Lien CL, et al. PLoS Biol, 2006 Aug. PMID 16869712, Free PMC Article
    5. Identification of the zebrafish IFN receptor: implications for the origin of the vertebrate IFN system. Levraud JP, et al. J Immunol, 2007 Apr 1. PMID 17371995

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thymosin beta
    Names
    thymosin b4
    zTB2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      34486717..34488993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481226.2 → XP_021336901.1  thymosin beta

      UniProtKB/TrEMBL
      A0A8M9QL22
      Related
      ENSDARP00000114378.1, ENSDART00000131861.3
      Conserved Domains (1) summary
      cl27586
      Location:3 → 40
      Thymosin; Thymosin beta-4 family
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials