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    atp2b3a ATPase plasma membrane Ca2+ transporting 3a [ Danio rerio (zebrafish) ]

    Gene ID: 436745, updated on 4-Jan-2025

    Summary

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    Official Symbol
    atp2b3aprovided by ZNC
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-174
    See related
    Ensembl:ENSDARG00000043474 AllianceGenome:ZFIN:ZDB-GENE-040718-174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    atp2b3; pmca3a; zgc:92885; wu:fk54d07
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and P-type calcium transporter activity. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in plasma membrane. Is expressed in blood; liver; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1. Orthologous to human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See atp2b3a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (14003039..14052499, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (13964610..14014801, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-110g5.4 Neighboring gene insulin-like growth factor 3 Neighboring gene UDP glucuronosyltransferase 5 family, polypeptide E1 Neighboring gene death effector domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells. Liao BK, et al. BMC Genomics, 2007 Oct 4. PMID 17915033, Free PMC Article
    2. Heat Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy. Nagata Y, et al. Sci Rep, 2017 Dec 12. PMID 29234032, Free PMC Article
    3. Transcriptomic Profiling Revealed Signaling Pathways Associated with the Spawning of Female Zebrafish under Cold Stress. Ge G, et al. Int J Mol Sci, 2022 Jul 6. PMID 35886843, Free PMC Article
    4. Toxicological assessment of trace β-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis. Yin X, et al. PLoS One, 2014. PMID 25062015, Free PMC Article
    5. Effects of dietary methylmercury on the zebrafish brain: histological, mitochondrial, and gene transcription analyses. Cambier S, et al. Biometals, 2012 Feb. PMID 21947502

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    plasma membrane calcium-transporting ATPase 3a
    Names
    ATPase, Ca++ transporting, plasma membrane 3
    ATPase, Ca++ transporting, plasma membrane 3a
    plasma membrane calcium ATPase 3
    NP_001002472.2
    NP_001352362.1
    XP_005166875.1
    XP_005166876.1
    XP_005166877.1
    XP_005166879.1
    XP_021333914.1
    XP_021333915.1
    XP_068079027.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002472.3 → NP_001002472.2  plasma membrane calcium-transporting ATPase 3a isoform 2

      See identical proteins and their annotated locations for NP_001002472.2

      Status: VALIDATED

      Source sequence(s)
      BX248385
      UniProtKB/TrEMBL
      B0S5H1, B2CZB9
      Related
      ENSDARP00000087549.4, ENSDART00000093117.6
      Conserved Domains (7) summary
      TIGR01517
      Location:23 → 1060
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164 → 462
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:877 → 1055
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:57 → 116
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1100 → 1144
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:605 → 803
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:523 → 612
      Cation_ATPase; Cation transport ATPase (P-type)

    2. NM_001365433.1 → NP_001352362.1  plasma membrane calcium-transporting ATPase 3a isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX248385
      UniProtKB/TrEMBL
      A0A8M6Z7L0
      Conserved Domains (2) summary
      pfam12424
      Location:1122 → 1167
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:23 → 1082
      E1-E2_ATPase; E1-E2 ATPase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      14003039..14052499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478239.2 → XP_021333914.1  plasma membrane calcium-transporting ATPase 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q9N1
      Related
      ENSDARP00000119407.1, ENSDART00000135811.3
      Conserved Domains (2) summary
      pfam12424
      Location:1100 → 1146
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:23 → 1060
      E1-E2_ATPase; E1-E2 ATPase

    2. XM_005166819.5 → XP_005166876.1  plasma membrane calcium-transporting ATPase 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BE97
      Conserved Domains (7) summary
      TIGR01517
      Location:23 → 1060
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164 → 462
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:877 → 1055
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:57 → 116
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1100 → 1176
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:605 → 803
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:523 → 612
      Cation_ATPase; Cation transport ATPase (P-type)

    3. XM_068222926.1 → XP_068079027.1  plasma membrane calcium-transporting ATPase 3a isoform X7

    4. XM_005166820.5 → XP_005166877.1  plasma membrane calcium-transporting ATPase 3a isoform X3

      UniProtKB/TrEMBL
      A0A8M2BEB3
      Conserved Domains (7) summary
      TIGR01517
      Location:23 → 1082
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164 → 484
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:899 → 1077
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:57 → 116
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1122 → 1169
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:627 → 825
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:545 → 634
      Cation_ATPase; Cation transport ATPase (P-type)

    5. XM_005166818.5 → XP_005166875.1  plasma membrane calcium-transporting ATPase 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEB4
      Conserved Domains (7) summary
      TIGR01517
      Location:23 → 1082
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164 → 484
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:899 → 1077
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:57 → 116
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1122 → 1198
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:627 → 825
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:545 → 634
      Cation_ATPase; Cation transport ATPase (P-type)

    6. XM_021478240.2 → XP_021333915.1  plasma membrane calcium-transporting ATPase 3a isoform X6

      UniProtKB/TrEMBL
      A0A8M9QIJ9
      Conserved Domains (2) summary
      pfam12424
      Location:1100 → 1145
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:23 → 1060
      E1-E2_ATPase; E1-E2 ATPase

    7. XM_005166822.5 → XP_005166879.1  plasma membrane calcium-transporting ATPase 3a isoform X5

      UniProtKB/TrEMBL
      A0A8M2BE74
      Conserved Domains (7) summary
      TIGR01517
      Location:23 → 1082
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164 → 484
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:899 → 1077
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:57 → 116
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1122 → 1166
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:627 → 825
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:545 → 634
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version

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