rad1 RAD1 homolog (S. pombe) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rad1provided by ZNC
Official Full Name: RAD1 homolog (S. pombe)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1873
See related: Ensembl:ENSDARG00000040559 AllianceGenome:ZFIN:ZDB-GENE-040426-1873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56502; zgc:77779
Summary: Predicted to enable double-stranded DNA 3'-5' DNA exonuclease activity. Predicted to be involved in DNA damage checkpoint signaling and DNA repair. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (23780499..23784518, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (23845234..23849253, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables double-stranded DNA 3'-5' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of checkpoint clamp complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell cycle checkpoint protein RAD1

NP_957192.1

EC 3.1.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200898.1 → NP_957192.1 cell cycle checkpoint protein RAD1

See identical proteins and their annotated locations for NP_957192.1

Status: PROVISIONAL

Source sequence(s)

BC064305

UniProtKB/TrEMBL

A0A8M1PI65, Q6P2T4

Related

ENSDARP00000059353.5, ENSDART00000059354.6

Conserved Domains (2) summary

cd00577
Location:18 → 275

PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...

pfam02144
Location:15 → 256

Rad1; Repair protein Rad1/Rec1/Rad17