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    jade1 jade family PHD finger 1 [ Danio rerio (zebrafish) ]

    Gene ID: 327437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jade1provided by ZNC
    Official Full Name
    jade family PHD finger 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5648
    See related
    Ensembl:ENSDARG00000033707 AllianceGenome:ZFIN:ZDB-GENE-030131-5648
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    phf17; fi11a04; zgc:55323; wu:fi11a04
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within regulation of canonical Wnt signaling pathway. Predicted to be located in several cellular components, including chromosome; cytoskeleton; and nucleus. Predicted to be part of histone acetyltransferase complex. Orthologous to human JADE1 (jade family PHD finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See jade1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (26828030..26848026)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (26809656..26829635)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene progesterone receptor membrane component 2 Neighboring gene acetylserotonin O-methyltransferase 2 Neighboring gene si:dkey-221l4.10 Neighboring gene regulator of calcineurin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling. Borgal L, et al. J Biol Chem, 2012 Jul 20. PMID 22654112, Free PMC Article
    2. FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation. Fischer P, et al. BMC Biol, 2019 Jul 30. PMID 31362746, Free PMC Article
    3. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. Tzouanacou E, et al. Mol Cell Biol, 2003 Dec. PMID 14612400, Free PMC Article
    4. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
    5. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling.
      Title: The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein Jade-1
    Names
    PHD finger protein 17
    jade family PHD finger protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199805.1 → NP_956099.1  protein Jade-1

      See identical proteins and their annotated locations for NP_956099.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046874
      UniProtKB/Swiss-Prot
      Q803A0
      Related
      ENSDARP00000042059.3, ENSDART00000042060.5
      Conserved Domains (3) summary
      cd15671
      Location:251 → 361
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
      cd15679
      Location:198 → 243
      PHD_JADE1; PHD finger found in protein Jade-1 and similar proteins
      pfam10513
      Location:104 → 173
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      26828030..26848026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158492.5 → XP_005158549.1  protein Jade-1 isoform X1

      See identical proteins and their annotated locations for XP_005158549.1

      UniProtKB/TrEMBL
      A0A8M2B5C6, F1QA19
      Conserved Domains (3) summary
      cd15671
      Location:251 → 361
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
      cd15679
      Location:198 → 243
      PHD_JADE1; PHD finger found in protein Jade-1 and similar proteins
      pfam10513
      Location:104 → 173
      EPL1; Enhancer of polycomb-like

    2. XM_005158491.5 → XP_005158548.1  protein Jade-1 isoform X1

      See identical proteins and their annotated locations for XP_005158548.1

      UniProtKB/TrEMBL
      A0A8M2B5C6, F1QA19
      Related
      ENSDARP00000152238.1, ENSDART00000181269.1
      Conserved Domains (3) summary
      cd15671
      Location:251 → 361
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
      cd15679
      Location:198 → 243
      PHD_JADE1; PHD finger found in protein Jade-1 and similar proteins
      pfam10513
      Location:104 → 173
      EPL1; Enhancer of polycomb-like

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394994.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      64695..83990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q803A0.1 GenPept UniProtKB/Swiss-Prot:Q803A0

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