casq2 calsequestrin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: casq2provided by ZNC
Official Full Name: calsequestrin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-010724-12
See related: Ensembl:ENSDARG00000008982 AllianceGenome:ZFIN:ZDB-GENE-010724-12
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86817; wu:fa02h03
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Predicted to be located in sarcoplasmic reticulum. Predicted to be active in Z disc and sarcoplasmic reticulum lumen. Is expressed in adaxial cell; brain; cardiovascular system; musculature system; and somite. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 2. Orthologous to human CASQ2 (calsequestrin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (33097293..33107154, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (33286547..33296408, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Three zebrafish Casqs: Casq1a, Casq1b and Casq2 were identified by mass spectrometry (Data are available via ProteomeXchange with identifier PXD002455). Skeletal and cardiac zebrafish calsequestrins share properties with mammalian Casq1 and Casq2.
Title: Calsequestrins in skeletal and cardiac muscle from adult Danio rerio.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in sarcoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calsequestrin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002682.1 → NP_001002682.1 calsequestrin-2 precursor

See identical proteins and their annotated locations for NP_001002682.1

Status: PROVISIONAL

Source sequence(s)

BC075775

UniProtKB/TrEMBL

A0A8M1N138, Q6DI16

Related

ENSDARP00000020399.5, ENSDART00000013918.7

Conserved Domains (4) summary

cd03065
Location:25 → 144

PDI_b_Calsequestrin_N; PDIb family, Calsequestrin subfamily, N-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...

cd03066
Location:146 → 247

PDI_b_Calsequestrin_middle; PDIb family, Calsequestrin subfamily, Middle TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...

cd03074
Location:248 → 367

PDI_b'_Calsequestrin_C; Protein Disulfide Isomerase (PDIb') family, Calsequestrin subfamily, C-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient ...

pfam01216
Location:23 → 372

Calsequestrin; Calsequestrin