appbp2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: appbp2provided by ZNC
Official Full Name: amyloid beta precursor protein (cytoplasmic tail) binding protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1715
See related: Ensembl:ENSDARG00000007566 AllianceGenome:ZFIN:ZDB-GENE-030131-1715
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:76971; wu:fb78e11; wu:fc25c09
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within intracellular protein transport. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human APPBP2 (amyloid beta precursor protein binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (23922266..23942826, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (23987001..24007561, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: amyloid protein-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212633.1 → NP_997798.1 amyloid protein-binding protein 2

See identical proteins and their annotated locations for NP_997798.1

Status: PROVISIONAL

Source sequence(s)

BC066757

UniProtKB/TrEMBL

A0A8N7V097, E9QB67, Q6NY32

Related

ENSDARP00000027941.8, ENSDART00000002824.10

Conserved Domains (3) summary

sd00006
Location:429 → 457

TPR; TPR repeat [structural motif]

pfam13374
Location:428 → 466

TPR_10; Tetratricopeptide repeat

pfam13424
Location:427 → 504

TPR_12; Tetratricopeptide repeat