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    hectd1 HECT domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100002034, updated on 9-Dec-2024

    Summary

    Official Symbol
    hectd1provided by ZNC
    Official Full Name
    HECT domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-153
    See related
    Ensembl:ENSDARG00000054213 AllianceGenome:ZFIN:ZDB-GENE-030616-153
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92832; wu:fc30d02; wu:fc49f09; wu:fd99d04; zgc:123053; si:dz142b24.4
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to act upstream of or within protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in nuclear speck. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See hectd1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (28670263..28701283)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (28653169..28684320)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene MIS18 binding protein 1 Neighboring gene HEAT repeat containing 5a Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene striatin, calmodulin binding protein 3 Neighboring gene coagulation factor C homolog, cochlin (Limulus polyphemus)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • FLJ11186, MGC123053

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase HECTD1
    NP_001002504.2
    XP_009291386.1
    XP_009291387.1
    XP_009291388.1
    XP_009291389.1
    XP_009291390.1
    XP_009291392.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002504.2NP_001002504.2  E3 ubiquitin-protein ligase HECTD1

      See identical proteins and their annotated locations for NP_001002504.2

      Status: PROVISIONAL

      Source sequence(s)
      AL593845
      UniProtKB/TrEMBL
      A0A8M1N0I1, Q8JFV5
      Related
      ENSDARP00000139204.1, ENSDART00000159067.2
      Conserved Domains (7) summary
      smart00119
      Location:21212573
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:20972574
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      cl23730
      Location:11071240
      F5_F8_type_C; F5/8 type C domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      28670263..28701283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293111.4XP_009291386.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AJX0
      Conserved Domains (7) summary
      smart00119
      Location:21302582
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:21062583
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      cl23730
      Location:11071240
      F5_F8_type_C; F5/8 type C domain
    2. XM_009293114.4XP_009291389.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AJ23
      Conserved Domains (7) summary
      smart00119
      Location:20692521
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:20452522
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      cl23730
      Location:11071240
      F5_F8_type_C; F5/8 type C domain
    3. XM_009293112.4XP_009291387.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      A0A2R8PW57, A0A8M3AUC7
      Related
      ENSDARP00000145151.1, ENSDART00000182851.1
      Conserved Domains (7) summary
      smart00119
      Location:21152567
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:20912568
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      cl23730
      Location:11071240
      F5_F8_type_C; F5/8 type C domain
    4. XM_009293115.4XP_009291390.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      A0A0R4IGL6, A0A8M3B2H1
      Related
      ENSDARP00000133558.1, ENSDART00000164981.2
      Conserved Domains (7) summary
      smart00119
      Location:20542506
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:20302507
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      cl23730
      Location:11071240
      F5_F8_type_C; F5/8 type C domain
    5. XM_009293113.4XP_009291388.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ARF8
      Conserved Domains (7) summary
      smart00119
      Location:20832535
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:20592536
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06701
      Location:12771321
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      cl23730
      Location:11071240
      F5_F8_type_C; F5/8 type C domain
    6. XM_009293117.4XP_009291392.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AUD5
      Conserved Domains (7) summary
      smart00119
      Location:20682520
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:20442521
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06701
      Location:12771321
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      cl23730
      Location:11071240
      F5_F8_type_C; F5/8 type C domain