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    cyp2aa3 cytochrome P450, family 2, subfamily AA, polypeptide 3 [ Danio rerio (zebrafish) ]

    Gene ID: 386638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp2aa3provided by ZNC
    Official Full Name
    cytochrome P450, family 2, subfamily AA, polypeptide 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031030-8
    See related
    Ensembl:ENSDARG00000103347 AllianceGenome:ZFIN:ZDB-GENE-031030-8
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cyp2aa3v1; zgc:63546
    Summary
    Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp2aa3 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (42482137..42493876)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (42516641..42528380)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily AA, polypeptide 1 Neighboring gene y cytochrome P450, family 2, subfamily AA, polypeptide 2 Neighboring gene chromosome 23 C1orf87 homolog Neighboring gene uncharacterized LOC101887009

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cytochrome P450 2AA molecular clone, expression pattern, and different regulation by fish oil and lard oil in diets of grass carp (Ctenopharyngodon idella). Shi XC, et al. Fish Physiol Biochem, 2018 Aug. PMID 29725939
    2. New cytochrome P450 1B1, 1C1, 2Aa, 2Y3, and 2K genes from Chinese rare minnow (Gobiocypris rarus): Molecular characterization, basal expression and response of rare minnow CYP1s and CYP2s mRNA exposed to the AHR agonist benzo[a]pyrene. Yuan L, et al. Chemosphere, 2013 Sep. PMID 23711412
    3. Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Chen J, et al. Sci Rep, 2016 May 20. PMID 27197559, Free PMC Article
    4. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Kubota A, et al. Toxicol Appl Pharmacol, 2013 Oct 1. PMID 23726801, Free PMC Article
    5. Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Driessen M, et al. Toxicol Lett, 2014 Oct 1. PMID 25064622

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2AA3
    Names
    cytochrome P450 CYP2AA3v1
    cytochrome P450 monooxygenase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198369.2 → NP_938183.2  cytochrome P450 2AA3

      Status: VALIDATED

      Source sequence(s)
      BC163376
      UniProtKB/TrEMBL
      B3DJ50, B3DJ67
      Related
      ENSDARP00000137977.1, ENSDART00000160199.2
      Conserved Domains (1) summary
      pfam00067
      Location:40 → 480
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      42482137..42493876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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