gjd2b gap junction protein delta 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gjd2bprovided by ZNC
Official Full Name: gap junction protein delta 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030911-1
See related: Ensembl:ENSDARG00000070781 AllianceGenome:ZFIN:ZDB-GENE-030911-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cx35; gja9; cx35b; connexin35
Summary: Enables gap junction hemi-channel activity and voltage-gated monoatomic ion channel activity. Acts upstream of or within several processes, including monoatomic ion transmembrane transport; regulation of dendrite extension; and synapse assembly. Located in gap junction. Part of connexin complex. Is expressed in several structures, including heart; kidney; liver; nervous system; and neural tube. Orthologous to human GJD2 (gap junction protein delta 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (9960803..9963666, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (9973563..9976426, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons.
Title: Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons.
Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish.
Title: Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish.
This study detect cx35b mRNA in secondary motor neurons (SMNs) and interneurons in the spinal cord of Danio rerio embryos and larvae.
Title: Connexin 35b expression in the spinal cord of Danio rerio embryos and larvae.
Connexin 35 expression is first seen in the developing central nervous system at 1 day post fertilization.
Title: Distribution of the gap junction protein connexin 35 in the central nervous system of developing zebrafish larvae.
the magnitude of photoreceptor coupling is controlled by the dynamic phosphorylation and dephosphorylation of Cx35
Title: Photoreceptor coupling is controlled by connexin 35 phosphorylation in zebrafish retina.
The gamma hemichannel of Cx35 hemichannels exhibited a pronounced membrane potential dependence
Title: Biophysical characterization of zebrafish connexin35 hemichannels.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction hemi-channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of connexin complex	IDA Inferred from Direct Assay more info	PubMed
part_of connexin complex	IEA Inferred from Electronic Annotation more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gap junction protein delta 2b

Names: connexin 35; connexin 35b; cx35.1; gap junction protein alpha 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194420.1 → NP_919401.1 gap junction protein delta 2b

See identical proteins and their annotated locations for NP_919401.1

Status: PROVISIONAL

Source sequence(s)

AF462040

UniProtKB/TrEMBL

A0A2R8RRX4, F6NIU1, Q8JFD6

Related

ENSDARP00000095009.4, ENSDART00000104234.6

Conserved Domains (3) summary

smart00037
Location:45 → 77

CNX; Connexin homologues

smart01089
Location:192 → 258

Connexin_CCC; Gap junction channel protein cysteine-rich domain

pfam00029
Location:3 → 260

Connexin; Connexin