ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndufs2provided by ZNC
Official Full Name: NADH:ubiquinone oxidoreductase core subunit S2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-273
See related: Ensembl:ENSDARG00000007526 AllianceGenome:ZFIN:ZDB-GENE-050522-273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7149850; zgc:112036
Summary: Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NAD binding activity; and quinone binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (19043750..19068539, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (18791483..18816272, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk40d11.x1 (e-PCR)
- UniSTS:200972

fe48b05.y1 (e-PCR)
- UniSTS:196509

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Names: NADH dehydrogenase (ubiquinone) Fe-S protein 2

NP_001018481.2

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020645.2 → NP_001018481.2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Status: VALIDATED

Source sequence(s)

BC095651, CU972454, EG573536

UniProtKB/TrEMBL

A0A8M1N612, F1Q4N4

Related

ENSDARP00000098175.3, ENSDART00000108787.5

Conserved Domains (2) summary

PRK06075
Location:77 → 464

PRK06075; NADH dehydrogenase subunit D; Validated

COG0649
Location:76 → 464

NuoD; NADH:ubiquinone oxidoreductase 49 kD subunit (chain D) [Energy production and conversion]