nucb2a nucleobindin 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nucb2aprovided by ZNC
Official Full Name: nucleobindin 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030826-14
See related: Ensembl:ENSDARG00000036299 AllianceGenome:ZFIN:ZDB-GENE-030826-14
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb638; nucb2; wu:fa03d10
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within response to food. Predicted to be located in Golgi apparatus. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; gonad; and pectoral fin. Orthologous to human NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (27025235..27038425, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (26754042..26767232, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA495446 (e-PCR)
- UniSTS:206947

fa03d10.s1 (e-PCR)
- UniSTS:202169

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to food	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleobindin-2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201493.1 → NP_958901.1 nucleobindin-2a precursor

See identical proteins and their annotated locations for NP_958901.1

Status: PROVISIONAL

Source sequence(s)

BC046077

UniProtKB/TrEMBL

Q7ZUY4

Related

ENSDARP00000052730.5, ENSDART00000052731.7

Conserved Domains (3) summary

pfam13499
Location:248 → 320

EF-hand_7; EF-hand domain pair

cl08302
Location:251 → 320

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl23807
Location:388 → 486

WWbp; WW-domain ligand protein