U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 [ Danio rerio (zebrafish) ]

    Gene ID: 335032, updated on 4-Jan-2025

    Summary

    Official Symbol
    rapgef6provided by ZNC
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6972
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-6972
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa12b02
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within proteolysis and small GTPase-mediated signal transduction. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human RAPGEF6 (Rap guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See rapgef6 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (45043418..45073740, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (45019098..45049600, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 4 Neighboring gene ring finger protein 121 Neighboring gene follistatin-like 4 Neighboring gene si:ch73-269m14.2 Neighboring gene voltage-dependent anion channel 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      45043418..45073740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353005.2XP_017208494.2  rap guanine nucleotide exchange factor 6

      UniProtKB/TrEMBL
      A0A8M6Z3X1
      Conserved Domains (6) summary
      smart00100
      Location:290405
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00147
      Location:8661102
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:421534
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00992
      Location:538618
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:49154
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:759843
      UBQ; Ubiquitin-like proteins