srfa serum response factor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: srfaprovided by ZNC
Official Full Name: serum response factor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990714-29
See related: Ensembl:ENSDARG00000053918 AllianceGenome:ZFIN:ZDB-GENE-990714-29
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: srf; srf1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and serum response element binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including adaxial cell; digestive system; musculature system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (35089026..35124845)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (35113220..35152697)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a novel STARS-SRF feed-forward autoregulatory loop could play an essential role in STARS regulation and cardiac function
Title: STARS is essential to maintain cardiac development and function in vivo via a SRF pathway.
SRF was duplicated in the zebrafish genome and its protein expression in all three muscle cell types is highly conserved across vertebrate animals suggesting an ancient code for transcriptional regulation of genes unique to muscle cell lineages.
Title: Expression and comparative genomics of two serum response factor genes in zebrafish.

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General gene information

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Markers

srf (e-PCR), detects polymorphism
- UniSTS:205499

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables serum response element binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serum response factor a

Names: DreSrf1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110526.1 → NP_001103996.1 serum response factor a

Status: PROVISIONAL

Source sequence(s)

CR925810

UniProtKB/TrEMBL

A0A8M1NFF2, A8HAM3

Related

ENSDARP00000070519.5, ENSDART00000076040.7

Conserved Domains (1) summary

cd00266
Location:121 → 202

MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

35089026..35124845

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005174054.5 → XP_005174111.1 serum response factor a isoform X1

UniProtKB/TrEMBL

A0A8M2BLC6

Conserved Domains (1) summary

cd00266
Location:121 → 202

MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...