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    adam10b ADAM metallopeptidase domain 10b [ Danio rerio (zebrafish) ]

    Gene ID: 393392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adam10bprovided by ZNC
    Official Full Name
    ADAM metallopeptidase domain 10bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071115-1
    See related
    Ensembl:ENSDARG00000015502 AllianceGenome:ZFIN:ZDB-GENE-071115-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64203; wu:fc03d12
    Summary
    Predicted to enable metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to act upstream of or within proteolysis. Predicted to be active in synaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    all
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    Genomic context

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    See adam10b in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (150499..160758)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (65382..89319)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene contactin 1a Neighboring gene hepatic triacylglycerol lipase Neighboring gene disintegrin and metalloproteinase domain-containing protein 10-like Neighboring gene PCNA clamp associated factor Neighboring gene neuronal cell adhesion molecule b Neighboring gene von Willebrand factor A domain-containing protein 5A-like Neighboring gene aquaporin 9a Neighboring gene small nucleolar RNA SNORA71 Neighboring gene zgc:114188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects. Tokumasu Y, et al. Dev Growth Differ, 2016 May. PMID 27185351
    2. Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. Cañestro C, et al. PLoS Genet, 2009 May. PMID 19478994, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64203

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10b
    Names
    a disintegrin and metalloprotease domain 10b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200420.1 → NP_956714.1  disintegrin and metalloproteinase domain-containing protein 10b precursor

      See identical proteins and their annotated locations for NP_956714.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054638
      UniProtKB/TrEMBL
      Q7T294
      Conserved Domains (4) summary
      cd04270
      Location:225 → 464
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam00200
      Location:471 → 551
      Disintegrin; Disintegrin
      pfam01562
      Location:54 → 154
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:245 → 449
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      150499..160758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470558.2 → XP_021326233.1  disintegrin and metalloproteinase domain-containing protein 10b

      UniProtKB/TrEMBL
      A0A8M9PGZ4
      Related
      ENSDARP00000130824.2, ENSDART00000170892.2
      Conserved Domains (3) summary
      cd04270
      Location:229 → 468
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam00200
      Location:475 → 555
      Disintegrin
      pfam01562
      Location:56 → 164
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein Strain
    Heading Accession and Version

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