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    tpte transmembrane phosphatase with tensin homology [ Danio rerio (zebrafish) ]

    Gene ID: 327292, updated on 27-Dec-2024

    Summary

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    Official Symbol
    tpteprovided by ZNC
    Official Full Name
    transmembrane phosphatase with tensin homologyprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5503
    See related
    Ensembl:ENSDARG00000056985 AllianceGenome:ZFIN:ZDB-GENE-030131-5503
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    vsp; tpip; wu:fd20e11; wu:fi24b06
    Summary
    Enables monoatomic ion channel activity and phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Acts upstream of or within phosphatidylinositol dephosphorylation and regulation of endocytosis. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in blood vessel; gill; pleuroperitoneal region; and ventral mesoderm. Orthologous to human TPTE (transmembrane phosphatase with tensin homology) and TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tpte in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (24690684..24707956)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (24721177..24738504)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 1 Neighboring gene fibrinogen like 1B Neighboring gene sphingomyelin phosphodiesterase 1 Neighboring gene integrin-linked kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential Regulation of PI(4,5)P(2) Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin. Gomis-Perez C, et al. Front Mol Neurosci, 2017. PMID 28507506, Free PMC Article
    2. Evolution of the voltage sensor domain of the voltage-sensitive phosphoinositide phosphatase VSP/TPTE suggests a role as a proton channel in eutherian mammals. Sutton KA, et al. Mol Biol Evol, 2012 Sep. PMID 22396523, Free PMC Article
    3. Voltage-sensing phosphatase: actions and potentials. Okamura Y, et al. J Physiol, 2009 Feb 1. PMID 19074969, Free PMC Article
    4. Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor. Sakata S, et al. J Physiol, 2014 Mar 1. PMID 24277865, Free PMC Article
    5. Fluorescent protein voltage probes derived from ArcLight that respond to membrane voltage changes with fast kinetics. Han Z, et al. PLoS One, 2013. PMID 24312287, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP.
      Title: Role of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP.
    2. Measurements of the phosphatase activity toward phosphatidylinositol 4,5-bisphosphate revealed that both steps of voltage sensor activation are coupled to the tuning of phosphatase activities.
      Title: Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113432

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative tyrosine-protein phosphatase TPTE
    Names
    Dr-VSP
    voltage-sensing phosphoinositide phosphatase
    NP_001020629.1
    XP_005155316.1
    XP_005155317.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025458.1 → NP_001020629.1  putative tyrosine-protein phosphatase TPTE

      See identical proteins and their annotated locations for NP_001020629.1

      Status: PROVISIONAL

      Source sequence(s)
      BC096934
      UniProtKB/TrEMBL
      Q4V9E4
      Related
      ENSDARP00000074004.3, ENSDART00000079549.4
      Conserved Domains (3) summary
      smart00404
      Location:270 → 365
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      pfam00520
      Location:91 → 175
      Ion_trans; Ion transport protein
      pfam10409
      Location:373 → 510
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      24690684..24707956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155259.5 → XP_005155316.1  putative tyrosine-protein phosphatase TPTE isoform X1

      See identical proteins and their annotated locations for XP_005155316.1

      UniProtKB/TrEMBL
      A0A8M2B249, F1QG29
      Conserved Domains (3) summary
      smart00404
      Location:270 → 365
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      pfam00520
      Location:90 → 175
      Ion_trans; Ion transport protein
      pfam10409
      Location:373 → 510
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    2. XM_005155260.5 → XP_005155317.1  putative tyrosine-protein phosphatase TPTE isoform X1

      See identical proteins and their annotated locations for XP_005155317.1

      UniProtKB/TrEMBL
      A0A8M2B249, F1QG29
      Related
      ENSDARP00000157510.1, ENSDART00000181600.1
      Conserved Domains (3) summary
      smart00404
      Location:270 → 365
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      pfam00520
      Location:90 → 175
      Ion_trans; Ion transport protein
      pfam10409
      Location:373 → 510
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    Nucleotide Protein Strain
    Heading Accession and Version

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