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    nr5a2 nuclear receptor subfamily 5, group A, member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 30749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nr5a2provided by ZNC
    Official Full Name
    nuclear receptor subfamily 5, group A, member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-79
    See related
    Ensembl:ENSDARG00000100940 AllianceGenome:ZFIN:ZDB-GENE-990415-79
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ftz; sf1; LRH1; ff1a; zFF1; ftzf1; zFF1A; zFF1B
    Summary
    Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including cartilage development; digestive system development; and hepatoblast differentiation. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including digestive system; endocrine system; head; nervous system; and slow muscle cell. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nr5a2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (22632288..22721093, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (22608571..22696121, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489015 Neighboring gene adhesion G-protein coupled receptor D2 Neighboring gene uncharacterized LOC137488930 Neighboring gene uncharacterized LOC137488931 Neighboring gene microRNA mir-181b-3 Neighboring gene microRNA 181a-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A zebrafish ftz-F1 (Fushi tarazu factor 1) homologue requires multiple subdomains in the D and E regions for its transcriptional activity. Liu D, et al. J Biol Chem, 2000 Jun 2. PMID 10747875
    2. FTZ-F1alpha is expressed in the developing gonad of frogs. Takase M, et al. Biochim Biophys Acta, 2000 Nov 15. PMID 11072086
    3. Determination of the expression pattern of the dual promoter of zebrafish fushi tarazu factor-1a following microinjections into zebrafish one cell stage embryos. von Hofsten J, et al. Gen Comp Endocrinol, 2005 May 15. PMID 15862566
    4. Transcriptional regulation of the rainbow trout CYP19a gene by FTZ-F1 homologue. Kanda H, et al. J Steroid Biochem Mol Biol, 2006 May. PMID 16621513
    5. Zebrafish ftz-f1a (nuclear receptor 5a2) functions in skeletal muscle organization. Sheela SG, et al. Dev Biol, 2005 Oct 15. PMID 16162335

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw.
      Title: Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw.
    2. chemical inhibition of Nr5a2 function during hepatopancreas progenitor specification was sufficient to disrupt exocrine pancreas formation and enhance the size of the embryonic liver, suggesting that Nr5a2 regulates hepatic vs. pancreatic progenitor fate choice.
      Title: Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development.
    3. The role of Sox9a in ff1a gene regulation and function was studied using sox9a morpholinos.
      Title: Sox9a regulation of ff1a in zebrafish (Danio rerio) suggests an involvement of ff1a in cartilage development.
    4. ff1a functions in both slow and fast muscle morphogenesis in response to Hedgehog signaling, and this function parallels the activity of another slow muscle gene, prox1
      Title: Zebrafish ftz-f1a (nuclear receptor 5a2) functions in skeletal muscle organization.
    5. The cloning and expression of 4 homologous genes in D. rerio are reported.
      Title: Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hepatoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor subfamily 5 group A member 2
    Names
    fushi tarazu
    steroidogenic factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313729.1 → NP_001300658.1  nuclear receptor subfamily 5 group A member 2

      Status: VALIDATED

      Source sequence(s)
      CR513789
      UniProtKB/TrEMBL
      A0A0R4IW70, A0A8N7XJG3, B3DJL1, Q90YL6
      Related
      ENSDARP00000141532.2, ENSDART00000166794.2
      Conserved Domains (3) summary
      cd07069
      Location:277 → 517
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:46 → 138
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
      pfam14596
      Location:204 → 294
      STAT6_C; STAT6 C-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      22632288..22721093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296226.4 → XP_009294501.1  nuclear receptor subfamily 5 group A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AXL9
      Conserved Domains (3) summary
      cd07069
      Location:267 → 507
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:36 → 128
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
      pfam14596
      Location:194 → 284
      STAT6_C; STAT6 C-terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_131463.1: Suppressed sequence

      Description
      NM_131463.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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