c3a.1 complement C3a, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: c3a.1provided by ZNC
Official Full Name: complement C3a, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-35
See related: Ensembl:ENSDARG00000012694 AllianceGenome:ZFIN:ZDB-GENE-990415-35
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: C3; c3a; C3-1; cb26; sb:cb26; wu:fi34b03; wu:fj86e11; si:dkey-76b14.4
Summary: Predicted to enable endopeptidase inhibitor activity and serine-type endopeptidase activity. Acts upstream of or within chordate embryonic development and positive regulation of neutrophil migration. Predicted to be located in extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (56130222..56176975, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (55460926..55507679, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage.
Title: Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage.
Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development.
Title: Complement fragment C3a controls mutual cell attraction during collective cell migration.

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General gene information

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Markers

fd50h10.x1 (e-PCR)
- UniSTS:195591

fb60d08.y1 (e-PCR)
- UniSTS:190853

AF047413 (e-PCR)
- UniSTS:204692

fc19e06.y1 (e-PCR)
- UniSTS:192931

fi34b03.x1 (e-PCR)
- UniSTS:197329

fj86e11.x1 (e-PCR)
- UniSTS:200155

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: complement C3a.1

Names: c3.1; complement component 3; complement component c3a, duplicate 1

NP_571317.1

EC 3.4.21.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131242.1 → NP_571317.1 complement C3a.1 precursor

Status: VALIDATED

Source sequence(s)

AW170905, BQ074354, BQ074523, BU709691, CF595146, CK868177, CN329603, DT075162, EB927372, EE304206, EE312111, EE711390

UniProtKB/TrEMBL

A0A8M1P7C1

Related

ENSDARP00000052687.6, ENSDART00000052688.7

Conserved Domains (8) summary

cd00017
Location:666 → 735

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cd02896
Location:979 → 1264

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

cd03583
Location:1494 → 1641

NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...

pfam00207
Location:759 → 851

A2M; Alpha-2-macroglobulin family

pfam01835
Location:129 → 223

A2M_N; MG2 domain

pfam07677
Location:1380 → 1475

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1034 → 1264

A2M_comp; A-macroglobulin complement component

pfam07703
Location:452 → 588

A2M_N_2; Alpha-2-macroglobulin family N-terminal region