pias4a protein inhibitor of activated STAT, 4a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pias4aprovided by ZNC
Official Full Name: protein inhibitor of activated STAT, 4aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2734
See related: Ensembl:ENSDARG00000007081 AllianceGenome:ZFIN:ZDB-GENE-040426-2734
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pias4; piasy; zgc:66410; wu:fc54c11; wu:fi18c10; wu:fi20e09; wu:fk93f11
Summary: Predicted to enable SUMO ligase activity and transcription coregulator activity. Acts upstream of or within negative regulation of type I interferon production and negative regulation of type I interferon-mediated signaling pathway. Located in nucleus. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (20406858..20419670, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (20381880..20394692, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a PIAS4 homologue (zfPIAS4a) from the zebrafish model that shares many conserved structural hallmarks with the human and mammal PIAS4 proteins was successfully identified
Title: Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution.

Submit: New GeneRIF Correction

General gene information

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Markers

fk93f11.x1 (e-PCR)
- UniSTS:201742

fi18c10.x1 (e-PCR)
- UniSTS:196951

fc54c11 (e-PCR)
- UniSTS:189335

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables SUMO ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 SUMO-protein ligase PIAS4-A

Names: E3 SUMO-protein ligase PIAS4; protein inhibitor of activated STAT 4; protein inhibitor of activated STAT protein 4

NP_998568.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213403.2 → NP_998568.2 E3 SUMO-protein ligase PIAS4-A

See identical proteins and their annotated locations for NP_998568.2

Status: PROVISIONAL

Source sequence(s)

BC070017

UniProtKB/Swiss-Prot

F1R4C4, H8YLC1, Q6IS20, Q6PFJ4

Related

ENSDARP00000096293.3, ENSDART00000105520.4

Conserved Domains (3) summary

smart00513
Location:12 → 46

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam02891
Location:307 → 356

zf-MIZ; MIZ/SP-RING zinc finger

pfam14324
Location:116 → 254

PINIT; PINIT domain