cluap1 clusterin associated protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cluap1provided by ZNC
Official Full Name: clusterin associated protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1943
See related: Ensembl:ENSDARG00000079110 AllianceGenome:ZFIN:ZDB-GENE-040426-1943
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj16b11; unm_au5; zgc:56115; wu:fj16b11
Summary: Acts upstream of or within cilium assembly; kidney development; and photoreceptor cell maintenance. Predicted to be located in cell projection and nucleus. Predicted to be part of intraciliary transport particle B. Predicted to be active in cilium and microtubule organizing center. Orthologous to human CLUAP1 (clusterin associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (37466770..37484128, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (37579050..37596410, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Consistent with the knowledge that CLUAP1 plays an important role in cilia function and that cilia are critical to photoreceptor function, our results indicate that hypomorphic mutations in CLUAP1 can result in dysfunctional photoreceptors without systemic abnormalities. This is the first report linking mutations in CLUAP1 to human disease and establishes CLUAP1 as a candidate Leber congenital amaurosis gene
Title: Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1.
We identified a novel mutation in cluap1 and determined that photoreceptor maintenance is dependent on cluap1.
Title: Cluap1 is essential for ciliogenesis and photoreceptor maintenance in the vertebrate eye.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: clusterin-associated protein 1 homolog

Names: qil; qilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213008.1 → NP_998173.1 clusterin-associated protein 1 homolog

See identical proteins and their annotated locations for NP_998173.1

Status: PROVISIONAL

Source sequence(s)

BC045921

UniProtKB/Swiss-Prot

Q4V941, Q6NWG3, Q7ZVC2

Related

ENSDARP00000101015.2, ENSDART00000111623.4

Conserved Domains (2) summary

pfam10234
Location:19 → 278

Cluap1; Clusterin-associated protein-1

cl12013
Location:161 → 278

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

37466770..37484128 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068217047.1 → XP_068073148.1 clusterin-associated protein 1 homolog isoform X4

UniProtKB/Swiss-Prot

Q4V941, Q6NWG3, Q7ZVC2
XM_021470122.2 → XP_021325797.1 clusterin-associated protein 1 homolog isoform X3

UniProtKB/Swiss-Prot

Q4V941, Q6NWG3, Q7ZVC2

UniProtKB/TrEMBL

A0A8M9P5T3

Conserved Domains (1) summary

pfam10234
Location:19 → 279

Cluap1; Clusterin-associated protein-1
XM_021470121.2 → XP_021325796.1 clusterin-associated protein 1 homolog isoform X2

UniProtKB/Swiss-Prot

Q4V941, Q6NWG3, Q7ZVC2

UniProtKB/TrEMBL

A0A8M9PTX5

Conserved Domains (1) summary

pfam10234
Location:19 → 279

Cluap1; Clusterin-associated protein-1
XM_021470120.2 → XP_021325795.1 clusterin-associated protein 1 homolog isoform X1

UniProtKB/Swiss-Prot

Q4V941, Q6NWG3, Q7ZVC2

UniProtKB/TrEMBL

A0A8M9PXC0

Conserved Domains (1) summary

pfam10234
Location:19 → 279

Cluap1; Clusterin-associated protein-1