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    scarb2c scavenger receptor class B, member 2c [ Danio rerio (zebrafish) ]

    Gene ID: 337532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scarb2cprovided by ZNC
    Official Full Name
    scavenger receptor class B, member 2cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5789
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-5789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi18e02; fj81e10; wu:fi18e02; wu:fj81e10
    Summary
    Predicted to enable scavenger receptor activity. Predicted to be located in lysosome and membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 4. Orthologous to human SCARB2 (scavenger receptor class B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See scarb2c in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (974445..1009150)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (733616..767468, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene thioredoxin-like 1 Neighboring gene asparaginyl-tRNA synthetase 1 Neighboring gene liver-expressed antimicrobial peptide 2-like Neighboring gene uncharacterized LOC137488770 Neighboring gene uncharacterized bromodomain-containing protein 10-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish scarb2a insertional mutant reveals a novel function for the Scarb2/Limp2 receptor in notochord development. Diaz-Tellez A, et al. Dev Dyn, 2016 Apr. PMID 26743566
    2. An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Lin X, et al. Dev Cell, 2019 May 20. PMID 31006648
    3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysosome membrane protein 2c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365142.1 → NP_001352071.1  lysosome membrane protein 2c

      Status: VALIDATED

      Source sequence(s)
      CABZ01057159, LO018018
      UniProtKB/TrEMBL
      A0A8M9PU63
      Conserved Domains (1) summary
      pfam01130
      Location:15 → 457
      CD36; CD36 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      974445..1009150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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