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    mhc2dcb major histocompatibility complex class II DCB gene [ Danio rerio (zebrafish) ]

    Gene ID: 30763, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mhc2dcbprovided by ZNC
    Official Full Name
    major histocompatibility complex class II DCB geneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-143
    See related
    Ensembl:ENSDARG00000088872 AllianceGenome:ZFIN:ZDB-GENE-990415-143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    DCB; Mhciibf; si:dz37i06.4; si:dz37i06.8; si:dz243a08.1; si:busm1-37i06.4; si:busm1-37i06.8; si:busm1-243a08.1
    Summary
    Is expressed in liver and spleen. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mhc2dcb in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (44362126..44363639, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (44368720..44370194, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 10 Neighboring gene major histocompatibility complex class II DCA gene Neighboring gene H-2 class II histocompatibility antigen, A-U alpha chain Neighboring gene major histocompatibility complex class II d8.45b1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Immune responses evoked by infection with Vibrio anguillarum in zebrafish bath-vaccinated with a live attenuated strain. Zhang Z, et al. Vet Immunol Immunopathol, 2013 Aug 15. PMID 23768660
    2. Immune responses of zebrafish (Danio rerio) induced by bath-vaccination with a live attenuated Vibrio anguillarum vaccine candidate. Zhang Z, et al. Fish Shellfish Immunol, 2012 Jul. PMID 22507197
    3. The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Sun Z, et al. Fish Shellfish Immunol, 2015 Oct. PMID 26256425
    4. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Wu XM, et al. Dev Comp Immunol, 2017 Mar. PMID 27876605
    5. Edwardsiella tarda flagellar protein FlgD: a protective immunogen against edwardsiellosis. Zhang M, et al. Vaccine, 2012 Jun 6. PMID 22521284

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    major histocompatibility complex class II DCB
    Names
    MHC Brre-DCB
    MHC class II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007035.1 → NP_001007036.1  major histocompatibility complex class II DCB precursor

      See identical proteins and their annotated locations for NP_001007036.1

      Status: PROVISIONAL

      Source sequence(s)
      AL591175
      UniProtKB/TrEMBL
      Q31357

    2. NM_131706.2 → NP_571781.2  major histocompatibility complex class II DCB precursor

      Status: VALIDATED

      Source sequence(s)
      CU914776
      UniProtKB/TrEMBL
      Q31357
      Conserved Domains (2) summary
      pfam07654
      Location:114 → 196
      C1-set; Immunoglobulin C1-set domain
      cl03042
      Location:29 → 80
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      44362126..44363639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223219.1 → XP_068079320.1  major histocompatibility complex class II DCB

      UniProtKB/TrEMBL
      Q31357
      Related
      ENSDARP00000110668.1, ENSDART00000123658.3
    Nucleotide Protein
    Heading Accession and Version

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