prdx2 peroxiredoxin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prdx2provided by ZNC
Official Full Name: peroxiredoxin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030326-2
See related: Ensembl:ENSDARG00000025350 AllianceGenome:ZFIN:ZDB-GENE-030326-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb58; prdx1; NKEF-B; zgc:92891; wu:fq19b09
Summary: Predicted to enable thioredoxin peroxidase activity. Predicted to be involved in several processes, including cell redox homeostasis; hydrogen peroxide catabolic process; and removal of superoxide radicals. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; hematopoietic system; nervous system; neural tube; and presumptive blood. Orthologous to human PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (51721851..51729866)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (51087487..51095502)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peroxiredoxin-2

Names: peroxiredoxin 1

NP_001002468.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002468.2 → NP_001002468.1 peroxiredoxin-2

See identical proteins and their annotated locations for NP_001002468.1

Status: VALIDATED

Source sequence(s)

EB860866, EH486177, EH575743

UniProtKB/TrEMBL

A0A8M1N0L1, Q6DGJ6

Related

ENSDARP00000040396.4, ENSDART00000040397.5

Conserved Domains (2) summary

PTZ00253
Location:1 → 195

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:8 → 179

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...