psmd4b proteasome 26S subunit ubiquitin receptor, non-ATPase 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psmd4bprovided by ZNC
Official Full Name: proteasome 26S subunit ubiquitin receptor, non-ATPase 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-96
See related: Ensembl:ENSDARG00000023279 AllianceGenome:ZFIN:ZDB-GENE-050417-96
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: psmd4; im:6912672; wu:fc68c04; zgc:110247
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (9762279..9777919)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (9871377..9887017)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 4b

Names: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b; proteasome 26S subunit, non-ATPase 4b; psmd4l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017624.2 → NP_001017624.1 26S proteasome non-ATPase regulatory subunit 4b

See identical proteins and their annotated locations for NP_001017624.1

Status: PROVISIONAL

Source sequence(s)

BC092825

UniProtKB/TrEMBL

B2GPS9, F6NWT3, Q561Y1

Related

ENSDARP00000003398.8, ENSDART00000020654.9

Conserved Domains (1) summary

cd01452
Location:1 → 187

VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...