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    aldh3a2a aldehyde dehydrogenase 3 family, member A2a [ Danio rerio (zebrafish) ]

    Gene ID: 323653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aldh3a2aprovided by ZNC
    Official Full Name
    aldehyde dehydrogenase 3 family, member A2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-74
    See related
    Ensembl:ENSDARG00000028259 AllianceGenome:ZFIN:ZDB-GENE-040718-74
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    aldh3a2; Aldh-III; zgc:92064; wu:fc06b11
    Summary
    Predicted to enable 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See aldh3a2a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20830664..20839224, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20894932..20904138, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene tyrosylprotein sulfotransferase 1 Neighboring gene aldehyde dehydrogenase 3 family, member A1 Neighboring gene unc-51 like autophagy activating kinase 2 Neighboring gene GTPase IMAP family member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative studies of vertebrate aldehyde dehydrogenase 3: sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene. Holmes RS, et al. Chem Biol Interact, 2011 May 30. PMID 21296057
    2. Enantioselectivity of toxicological responses induced by maternal exposure of cis-bifenthrin enantiomers in zebrafish (Danio rerio) larvae. Xiang D, et al. J Hazard Mater, 2019 Jun 5. PMID 30889462
    3. The combination of loss of glyoxalase1 and obesity results in hyperglycemia. Lodd E, et al. JCI Insight, 2019 Jun 20. PMID 31217350, Free PMC Article
    4. ALDH2 mediates 5-nitrofuran activity in multiple species. Zhou L, et al. Chem Biol, 2012 Jul 27. PMID 22840776, Free PMC Article
    5. Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Brunsdon H, et al. Development, 2022 May 15. PMID 35485397, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3-chloroallyl aldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aldehyde metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase family 3 member A2a
    Names
    aldehyde dehydrogenase 3 family, member A2
    sls
    NP_997814.1
    XP_009289895.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212649.1 → NP_997814.1  aldehyde dehydrogenase family 3 member A2a

      See identical proteins and their annotated locations for NP_997814.1

      Status: PROVISIONAL

      Source sequence(s)
      AF254954
      UniProtKB/TrEMBL
      A9JT25, Q90ZZ8
      Related
      ENSDARP00000037108.6, ENSDART00000031625.9
      Conserved Domains (1) summary
      cd07132
      Location:5 → 446
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      20830664..20839224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291620.4 → XP_009289895.1  aldehyde dehydrogenase family 3 member A2a isoform X1

      See identical proteins and their annotated locations for XP_009289895.1

      UniProtKB/TrEMBL
      A9JT25, Q90ZZ8
      Related
      ENSDARP00000152087.1, ENSDART00000182369.1
      Conserved Domains (1) summary
      cd07132
      Location:5 → 446
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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