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    cacng1a calcium channel, voltage-dependent, gamma subunit 1a [ Danio rerio (zebrafish) ]

    Gene ID: 322013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cacng1aprovided by ZNC
    Official Full Name
    calcium channel, voltage-dependent, gamma subunit 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-732
    See related
    Ensembl:ENSDARG00000008772 AllianceGenome:ZFIN:ZDB-GENE-030131-732
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cacng1; zgc:55364; wu:fb43f02; wu:fi19g08
    Summary
    Predicted to enable calcium channel regulator activity. Predicted to be involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in malignant hyperthermia. Orthologous to human CACNG1 (calcium voltage-gated channel auxiliary subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cacng1a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (21458075..21492643, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (19411447..19432421, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene protein kinase C, alpha, a Neighboring gene calcium channel, voltage-dependent, gamma subunit 5a Neighboring gene uncharacterized LOC137495960 Neighboring gene calcium channel, voltage-dependent, gamma subunit 4a Neighboring gene proteasome 26S subunit, non-ATPase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An embryonic 100μg/L lead exposure results in sex-specific expression changes in genes associated with the neurological system in female or cancer in male adult zebrafish brains. Lee J, et al. Neurotoxicol Teratol, 2018 Jan-Feb. PMID 29074346
    2. Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1. Todd PK, et al. Dis Model Mech, 2014 Jan. PMID 24092878, Free PMC Article
    3. Protein kinase C alpha and beta are positive regulators of thrombus formation in vivo in a zebrafish (Danio rerio) model of thrombosis. Williams CM, et al. J Thromb Haemost, 2011 Dec. PMID 21951302
    4. Structure-toxicity relationship of cefoperazone and its impurities to developing zebrafish by transcriptome and Raman analysis. Han Y, et al. Toxicol Appl Pharmacol, 2017 Jul 15. PMID 28465218
    5. asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. Cai W, et al. Int J Mol Sci, 2023 Nov 15. PMID 38003559, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of L-type voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium channel, voltage-dependent, gamma subunit 1a
    Names
    calcium channel, voltage-dependent, gamma subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214684.1 → NP_999849.1  calcium channel, voltage-dependent, gamma subunit 1a

      See identical proteins and their annotated locations for NP_999849.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044150
      UniProtKB/TrEMBL
      Q803X9
      Related
      ENSDARP00000028126.7, ENSDART00000006843.8
      Conserved Domains (1) summary
      pfam13903
      Location:15 → 199
      Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      21458075..21492643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476780.2 → XP_021332455.1  calcium channel, voltage-dependent, gamma subunit 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M9QF71
      Conserved Domains (1) summary
      pfam13903
      Location:15 → 203
      Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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