acss2 acyl-CoA synthetase short chain family member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acss2provided by ZNC
Official Full Name: acyl-CoA synthetase short chain family member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-388
See related: Ensembl:ENSDARG00000037781 AllianceGenome:ZFIN:ZDB-GENE-040718-388
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa04c03; fj80b06; fj80h04; zgc:92200; wu:fa04c03; wu:fj80b06; wu:fj80h04
Summary: Predicted to enable acetate-CoA ligase activity. Predicted to be involved in acetyl-CoA biosynthetic process. Predicted to act upstream of or within acetyl-CoA biosynthetic process from acetate and lipid metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (9230540..9288449)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (9295568..9353479)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fj80b06.x1 (e-PCR)
- UniSTS:199951

fj68h04.x1 (e-PCR)
- UniSTS:204633

fa04c03.s1 (e-PCR)
- UniSTS:202192

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables AMP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables propionate-CoA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetyl-CoA biosynthetic process from acetate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acetyl-coenzyme A synthetase, cytoplasmic

NP_001315282.1

EC 6.2.1.1

XP_005162010.1

EC 6.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328353.1 → NP_001315282.1 acetyl-coenzyme A synthetase, cytoplasmic

Status: VALIDATED

Source sequence(s)

CT027560, CU137717

UniProtKB/TrEMBL

A0A8M1P9T3, F1QAA7

Related

ENSDARP00000112054.3, ENSDART00000125122.4

Conserved Domains (2) summary

cd05966
Location:34 → 682

ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

PRK00174
Location:15 → 693

PRK00174; acetyl-CoA synthetase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

9230540..9288449

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005161953.5 → XP_005162010.1 acetyl-coenzyme A synthetase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A2R8Q6G5, A0A8M2B8S0

Related

ENSDARP00000146673.1, ENSDART00000187676.1

Conserved Domains (2) summary

cd05966
Location:34 → 666

ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

PRK00174
Location:15 → 677

PRK00174; acetyl-CoA synthetase; Provisional

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395127.1 Reference GRCz11 ALT_DRER_TU_1

Range

8339..47353

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001002641.1: Suppressed sequence

Description

NM_001002641.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.