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    snx4 sorting nexin 4 [ Danio rerio (zebrafish) ]

    Gene ID: 323203, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx4provided by ZNC
    Official Full Name
    sorting nexin 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1923
    See related
    Ensembl:ENSDARG00000022659 AllianceGenome:ZFIN:ZDB-GENE-030131-1923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6971267; wu:fb92d09; zgc:113437
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in positive regulation of autophagosome assembly and protein transport. Predicted to be part of SNARE complex. Predicted to be active in early endosome membrane and plasma membrane. Is expressed in notochord. Orthologous to human SNX4 (sorting nexin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See snx4 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (38588091..38621202)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (38778296..38811407)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 11 Neighboring gene transforming growth factor beta receptor-like Neighboring gene zinc finger protein 148 Neighboring gene solute carrier family 12 member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
    2. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014346.1 → NP_001014368.1  sorting nexin-4

      See identical proteins and their annotated locations for NP_001014368.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091982
      UniProtKB/TrEMBL
      Q58EC1
      Related
      ENSDARP00000033122.4, ENSDART00000031127.6
      Conserved Domains (2) summary
      cd06864
      Location:41 → 168
      PX_SNX4; The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
      cd07622
      Location:189 → 432
      BAR_SNX4; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      38588091..38621202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223291.1 → XP_068079392.1  sorting nexin-4 isoform X1

    2. XM_068223292.1 → XP_068079393.1  sorting nexin-4 isoform X2

    3. XM_068223293.1 → XP_068079394.1  sorting nexin-4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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