hp haptoglobin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hpprovided by ZNC
Official Full Name: haptoglobinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1259
See related: Ensembl:ENSDARG00000051890 AllianceGenome:ZFIN:ZDB-GENE-030131-1259
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb64e01
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Is expressed in intestine and male organism. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; artery disease (multiple); gout; hyperglycemia; and obesity. Orthologous to human HP (haptoglobin) and HPR (haptoglobin-related protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (56577559..56585291)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (50154455..50159367, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI496840 (e-PCR)
- UniSTS:206398

fb64e01 (e-PCR), detects polymorphism
- UniSTS:189053

fb63e01.y1 (e-PCR)
- UniSTS:190900

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: haptoglobin

Names: HpL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001366015.1 → NP_001352944.1 haptoglobin precursor

Status: VALIDATED

Source sequence(s)

CR382281

UniProtKB/TrEMBL

A0A8M9QD27

Related

ENSDARP00000125025.1, ENSDART00000149130.3

Conserved Domains (1) summary

cd00190
Location:40 → 284

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...